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Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.
Gene Name: | TNFAIP3 interacting protein 3 |
Synonyms: | TNIP3, ABIN-3, ABIN-3 beta, ABIN3, Listeria induced, LIND, Listeria-induced gene protein, TNIP3 beta, TNFAIP3 interacting protein 3, TNFAIP3-interacting protein 3 |
Target Sequences: | NM_024873 NP_079149.3 Q96KP6 |
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