Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
Gene Name: | TRAF2 and NCK interacting kinase |
Family/Subfamily: | Protein Kinase , MSN |
Synonyms: | TNIK, ZC2, KIAA0551 |
Target Sequences: | NM_015028 BAA25477.2 Q9UKE5 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.