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TNFSF4 / OX40L / CD252

tumor necrosis factor (ligand) superfamily, member 4

TNFSF4 / OX40L is a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.

Gene Name: tumor necrosis factor (ligand) superfamily, member 4
Family/Subfamily: TNF , not assigned-TNF
Synonyms: TNFSF4, CD134 ligand, CD134L, CD252 antigen, Glycoprotein Gp34, OX-40L, OX40 ligand, TXGP1, OX40L, OX4OL, CD252, gp34, OX40 antigen ligand
Target Sequences: NM_003326 NP_003317.1 P23510

Publications (3)

1
Soluble OX40L is associated with presence of autoantibodies in early rheumatoid arthritis. Laustsen JK, Rasmussen TK, Stengaard-Pedersen K, Hørslev-Petersen K, Hetland ML, Østergaard M, Junker P, Hvid M, Deleuran B. Arthritis research & therapy. 2014 16:474. (Flo; Human) [Full Text Article] [PubMed:25359291] [PMC:PMC4230735] Related Antibodies: LS-C35826.
2
Roles of OX40 and OX40 Ligand in Mycosis Fungoides and Sézary Syndrome. Yuki Kawana, Hiraku Suga, Hiroaki Kamijo, Tomomitsu Miyagaki, Makoto Sugaya, Shinichi Sato. International journal of molecular sciences. 2021 Nov;22:12576. [Full Text Article] [PubMed:34830466] [PMC:PMC8617822] Related Antibodies: LS-B14343.
3
High Serum OX40 and OX40 Ligand (OX40L) Levels Correlate with Reduced Survival in Patients with Advanced Lung Adenocarcinoma. Jumpei Kashima, Yusuke Okuma, Yukio Hosomi, Tsunekazu Hishima. Oncology. 2020 February;98:303-310. [Full Text Article] [PubMed:32097938]

☰ Filters
Products
Proteins (23)
Over-Expression Lysate (2)
Recombinant (21)
TNFSF4 / OX40L / CD252 (23)
No (23)
6His, N-terminus (2)
8His, N-terminus (3)
DDK (Flag)-Human ACRP30headless aa 18-111 (1)
Fc, C-terminus (2)
Fc, N-terminus (1)
Fc-AVI, C-terminus (1)
GST (1)
His,C-terminus (2)
His,N-terminus (1)
mFc, C-terminus (2)
Mouse IgG1 Fc (1)
Mouse IgG2a Fc, N-terminus (1)
Myc-DDK (Flag) (3)
Crab-eating macaque (2)
Cynomolgus monkey (1)
Human (14)
Mouse (5)
293T Cells (1)
HEK 293 Cells (7)
High Five Cells (1)
Human Cells (4)
Mammalian Cells (9)
Wheat Germ Extract (1)
Purified (6)
Low endotoxin level (18)
Biologically active (4)
Select
Human Cells
8His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
16.5kD
10 µg/$264; 50 µg/$367; 500 µg/$1,716
Select
Human Cells
8His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
17.7kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
TNFSF4 / OX40L / CD252 Protein - Human OX40L induces proliferation of PHA-activated T cells.
Select
HEK 293 Cells
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
The 154 amino acid recombinant protein has a predicted molecular mass of approximately 17.6 kD. The protein migrates at approximately 34 kD in DTT-reducing conditions by SDS-PAGE. The predicted N-terminal amino acid is His.
25 µg/$497; 100 µg/$1,186
Select
Human Cells
Mouse IgG1 Fc
Less than 1.0 EU/µg protein (determined by LAL method).
42.1 kDa
100 µg/$838; 1 mg/$4,103
Select
Human Cells
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
16.3kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353
Select
High Five Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
15.5-25.0 kDa
2 µg/$268; 10 µg/$349
TNFSF4 / OX40L / CD252 Protein - Purified recombinant protein TNFSF4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
20.9 kDa
20 µg/$1,107
TNFSF4 / OX40L / CD252 Protein - 12.5% SDS-PAGE of human TNFSF4 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
47.5 kDa
2 µg/$439
TNFSF4 / OX40L / CD252 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
20.9 kDa
20 µg/$150
TNFSF4 / OX40L / CD252 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
20.9 kDa
100 µg/$494
TNFSF4 / OX40L / CD252 Protein
Select
HEK 293 Cells
Fc, C-terminus
42 kDa
20 µg/$1,107
Select
HEK 293 Cells
Mouse IgG2a Fc, N-terminus
Biologically active
Less than 5.0 EU/mg protein (determined by LAL method).
~55 kDa (SDS-PAGE)
100 µg/$463
Select
Mammalian Cells
Fc-AVI, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.6 kDa
20 µg/$416; 100 µg/$910
Select
Mammalian Cells
mFc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
46.8 kDa
10 µg/$281; 50 µg/$389
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.1 kDa
10 µg/$281; 50 µg/$389
Select
Mammalian Cells
Fc, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
47.4 kDa
10 µg/$281; 50 µg/$389
Select
HEK 293 Cells
DDK (Flag)-Human ACRP30headless aa 18-111
Less than 0.01 EU/µg protein (determined by LAL method).
~40kDa (SDS-PAGE)
10 µg/$344
Select
Mammalian Cells
mFc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.2 kDa
10 µg/$288; 50 µg/$436
Select
Mammalian Cells
8His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
17.7 kDa
10 µg/$288; 50 µg/$436
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.3 kDa
10 µg/$317; 50 µg/$524
Select
Mammalian Cells
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
16.3 kDa
10 µg/$317; 50 µg/$524
Select
Mammalian Cells
His,N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
16.5 kDa
10 µg/$339; 50 µg/$437
Select
HEK 293 Cells
His,C-terminus
Biologically active
Less than 0.01 EU/µg protein (determined by LAL method).
~27 kDa (SDS-PAGE)
50 µg/$442
Viewing 1-23 of 23 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).