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TNFSF15 / TL1A / VEGI
tumor necrosis factor (ligand) superfamily, member 15
TNFSF15 / TL1A / VEGI is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | tumor necrosis factor (ligand) superfamily, member 15 |
| Family/Subfamily: | TNF , not assigned-TNF |
| Synonyms: | TNFSF15, TL1, TL1A, TNF ligand-related molecule 1, TNF superfamily ligand TL1A, VEGI192A, VEGI |
| Target Sequences: | NM_005118 NP_005109.2 O95150 |
Publications (2)
1
Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells. Tso GH, Law HK, Tu W, Chan GC, Lau YL. Stem cells (Dayton, Ohio). 2010 28:939-54.
[PubMed:20222014]
2
The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1, IL-23, and TNF-like 1A expression by monocytes. Cunin P, Caillon A, Corvaisier M, Garo E, Scotet M, Blanchard S, Delneste Y, Jeannin P. Journal of immunology (Baltimore, Md. : 1950). 2011 186:4175-82.
[PubMed:21368235]
☰ Filters
Products
Proteins
(18)
Type
Over-Expression Lysate
(2)
Recombinant
(16)
Target
TNFSF15 / TL1A / VEGI
(18)
Application
SDS-PAGE
(3)
Publications
No
(18)
Tag
Fc, N-terminus
(1)
GST
(1)
GST, N-terminus
(1)
His
(1)
His-T7
(2)
Human IgG1 Fc, N-terminus
(1)
Mouse IgG1 Fc, N-terminus
(1)
Myc-DDK (Flag)
(2)
Rabbit IgG Fc, N-terminus
(1)
Species
Human
(14)
Mouse
(2)
Rat
(1)
Source
293T Cells
(1)
E. coli
(10)
HEK 293 Cells
(5)
Wheat Germ Extract
(2)
Purification
Purified
(3)
Low Endotoxin Level
Low endotoxin level
(11)
Biologically Active
Biologically active
(4)
E. coli
His
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$361; 500 µg/$739; 20 µg/$261
E. coli
None
Biologically active
20.5 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
50 µg/$291; 250 µg/$494; 2 mg/$2,575; 4 mg/$4,345
E. coli
His-T7
22.1 kDa
10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
20kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
22.0 kDa
5 µg/$268; 20 µg/$349
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
21.86kD
10 µg/$297; 50 µg/$468; 500 µg/$1,815; 1 mg/$2,588
Wheat Germ Extract
GST
54.5 kDa
10 µg/$479; 25 µg/$670
HEK 293 Cells
Human IgG1 Fc, N-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human TNFSF15 consists of 440 amino acids and predicts a molecular mass of 48.9 kDa.
100 µg/$480; 1 mg/$2,344
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
293T Cells
Myc-DDK (Flag)
27.9 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
27.9 kDa
100 µg/$494
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
21.9 kDa
10 µg/$297; 50 µg/$460
HEK 293 Cells
Mouse IgG1 Fc, N-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human TNFSF15 consists of 416 amino acids and predicts a molecular mass of 47.1 kDa.
100 µg/$480
HEK 293 Cells
Rabbit IgG Fc, N-terminus
SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human TNFSF15 consists of 431 amino acids and predicts a molecular mass of 48 kDa.
100 µg/$480; 1 mg/$2,333
HEK 293 Cells
Fc, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.9 kDa
100 µg/$666
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
20.0 kDa
10 µg/$317; 50 µg/$524
E. coli
His-T7
24.9 kDa
10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198
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