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TNFSF15 / TL1A / VEGI

tumor necrosis factor (ligand) superfamily, member 15

TNFSF15 / TL1A / VEGI is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: tumor necrosis factor (ligand) superfamily, member 15
Family/Subfamily: TNF , not assigned-TNF
Synonyms: TNFSF15, TL1, TL1A, TNF ligand-related molecule 1, TNF superfamily ligand TL1A, VEGI192A, VEGI
Target Sequences: NM_005118 NP_005109.2 O95150

Publications (2)

1
Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells. Tso GH, Law HK, Tu W, Chan GC, Lau YL. Stem cells (Dayton, Ohio). 2010 28:939-54. [PubMed:20222014]
2
The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1, IL-23, and TNF-like 1A expression by monocytes. Cunin P, Caillon A, Corvaisier M, Garo E, Scotet M, Blanchard S, Delneste Y, Jeannin P. Journal of immunology (Baltimore, Md. : 1950). 2011 186:4175-82. [PubMed:21368235]

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ELISA Kits (15)
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TNFSF15 / TL1A / VEGI (15)
Human (7)
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Guinea pig (1)
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Plasma (6)
Serum (6)
Tissue Homogenates (3)
TNFSF15 / TL1A / VEGI ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Human
63 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$414
TNFSF15 / TL1A / VEGI ELISA Kit
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Sandwich
96-Well Microplate
Human
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
TNFSF15 / TL1A / VEGI ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TNFSF15 / TL1A / VEGI ELISA Kit
Select
Cell-Based
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
TNFSF15 / TL1A / VEGI ELISA Kit
Select
Development Kit
1000 Wells
Human
63 - 4000 pg/ml
Colorimetric - 405nm (ABTS)
1 Test/$540
TNFSF15 / TL1A / VEGI ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
TNFSF15 / TL1A / VEGI ELISA Kit
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Custom
96-Well Strip Plate
Mouse
1 Plate/$669
TNFSF15 / TL1A / VEGI ELISA Kit
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Custom
96-Well Strip Plate
Human
1 Plate/$669
TNFSF15 / TL1A / VEGI ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$897
TNFSF15 / TL1A / VEGI ELISA Kit
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Custom
96-Well Strip Plate
Rat
1 Plate/$669
TNFSF15 / TL1A / VEGI ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
3.906 - 250 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
TNFSF15 / TL1A / VEGI ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
3.906 - 250 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
TNFSF15 / TL1A / VEGI ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
TNFSF15 / TL1A / VEGI ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
3.125 - 200 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
TNFSF15 / TL1A / VEGI ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$730
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).