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TNFSF15 / TL1A / VEGI
tumor necrosis factor (ligand) superfamily, member 15
TNFSF15 / TL1A / VEGI is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | tumor necrosis factor (ligand) superfamily, member 15 |
| Family/Subfamily: | TNF , not assigned-TNF |
| Synonyms: | TNFSF15, TL1, TL1A, TNF ligand-related molecule 1, TNF superfamily ligand TL1A, VEGI192A, VEGI |
| Target Sequences: | NM_005118 NP_005109.2 O95150 |
Publications (2)
1
Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells. Tso GH, Law HK, Tu W, Chan GC, Lau YL. Stem cells (Dayton, Ohio). 2010 28:939-54.
[PubMed:20222014]
2
The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1, IL-23, and TNF-like 1A expression by monocytes. Cunin P, Caillon A, Corvaisier M, Garo E, Scotet M, Blanchard S, Delneste Y, Jeannin P. Journal of immunology (Baltimore, Md. : 1950). 2011 186:4175-82.
[PubMed:21368235]
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TNFSF15 / TL1A / VEGI
(96)
Reactivity
Human
(61)
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(14)
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(15)
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(31)
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(4)
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(1)
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monoclonal mc
(7)
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(52)
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(4)
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rVEGI/1283
(2)
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(1)
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(11)
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(4)
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(1)
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(1)
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(96)
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(1)
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(14)
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(2)
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(1)
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(1)
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(10)
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(11)
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Biologically active
(4)
TNFSF15 / TL1A / VEGI Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
TNFSF15 / TL1A / VEGI Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$485
TNFSF15 / TL1A / VEGI Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
TNFSF15 / TL1A / VEGI Mouse anti-Human Monoclonal (TLRM1-1) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
TNFSF15 / TL1A / VEGI Mouse anti-Human Monoclonal (Azide-free, BSA-free) (TLRM1-1) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
TNFSF15 / TL1A / VEGI Rabbit anti-Human Polyclonal (aa148-175) (PE) Antibody
Human
ELISA, ICC, IF, WB
PE Conjugated
200 µl/$952
TNFSF15 / TL1A / VEGI Rabbit anti-Human Polyclonal (aa148-175) (Azide-free) (HRP) Antibody
Human
ELISA, ICC, IF, WB
HRP Conjugated, Azide-free
200 µl/$952
TNFSF15 / TL1A / VEGI Rabbit anti-Human Polyclonal (aa148-175) (APC) Antibody
Human
ELISA, ICC, IF, WB
APC Conjugated
200 µl/$952
TNFSF15 / TL1A / VEGI Rabbit anti-Human Polyclonal (aa148-175) Antibody
Human
Flo, IF, WB
Unconjugated
400 µl/$393
TNFSF15 / TL1A / VEGI Mouse anti-Human Monoclonal (L4G9) Antibody
Human
ELISA, Flo
Unconjugated
100 µg/$553
TNFSF15 / TL1A / VEGI Rabbit anti-Mouse Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$564
TNFSF15 / TL1A / VEGI Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
0.1 mg/$460
TNFSF15 / TL1A / VEGI Rabbit anti-Rat Polyclonal (aa70-230) Antibody
Rat
WB
Unconjugated
100 µl/$317; 200 µl/$363; 500 µl/$515; 1 ml/$591; 2 ml/$816; 5 ml/$1,331
Sandwich
12 x 8-Well Microstrips
Human
63 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$414
Sandwich
96-Well Microplate
Human
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
TNFSF15 / TL1A / VEGI Mouse anti-Human Monoclonal (Laety-1) Antibody
Mouse, Human
IP, WB
Unconjugated
100 µg/$571
TNFSF15 / TL1A / VEGI Mouse anti-Human Monoclonal (VEGI/1283) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
TNFSF15 / TL1A / VEGI Mouse anti-Human Monoclonal (Azide-free, BSA-free) (VEGI/1283) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
E. coli
His
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$361; 500 µg/$739; 20 µg/$261
E. coli
None
Biologically active
20.5 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
50 µg/$291; 250 µg/$494; 2 mg/$2,575; 4 mg/$4,345
E. coli
His-T7
22.1 kDa
10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278
TNFSF15 / TL1A / VEGI Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
TNFSF15 / TL1A / VEGI Rabbit anti-Human Polyclonal (150-230 aa, C-terminal) Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TNFSF15 / TL1A / VEGI Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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