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TNFSF12 / TWEAK

tumor necrosis factor (ligand) superfamily, member 12

TNFSF12 / TWEAK is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.

Gene Name: tumor necrosis factor (ligand) superfamily, member 12
Family/Subfamily: TNF , not assigned-TNF
Synonyms: TNFSF12, APO3/DR3 ligand, APO3L, DR3LG, APO3 ligand, TWEAK
Target Sequences: NM_003809 NP_003800.1 O43508

Publications (1)

1
Comparative transcriptome analysis of human and murine choroidal neovascularization identifies fibroblast growth factor inducible-14 as phylogenetically conserved mediator of neovascular age-related macular degeneration. Julian Wolf, Anja Schlecht, Dennis-Dominik Rosmus, Stefaniya Boneva, Hansjürgen Agostini, Günther Schlunck, Peter Wieghofer, Clemens Lange. Biochimica et biophysica acta. Molecular basis of disease. 2022 April;1868:166340. [Full Text Article] [PubMed:35032596]

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Antibodies (68)
Primary (68)
TNFSF12 / TWEAK (68)
Human (60)
Mouse (36)
Rat (13)
Chimpanzee (6)
Gibbon (6)
Horse (6)
IHC (20)
IHC-P (5)
WB (61)
Flo (5)
ELISA (18)
Func (3)
ICC (1)
IF (9)
IP (2)
Peptide-ELISA (3)
rabbit (55)
mouse (5)
goat (8)
Product Group
IHCPlus (3)
IgG (31)
IgG1 (1)
IgG3 (4)
monoclonal mc (5)
polyclonal pc (63)
CARL-1 (4)
Mira-2 (1)
APC (3)
APC Conjugated (4)
Biotin Conjugated (8)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (7)
HRP Conjugated (7)
Low Endotoxin (1)
PE Conjugated (5)
Unconjugated (31)
aa148-247 (8)
aa53-249 (8)
aa65-247 (8)
aa35-84 (4)
aa57-106 (4)
10-90 aa, Internal (1)
Internal (1)
Pro73 (1)
aa41-90 (1)
aa42-123 (1)
No (68)
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TNFSF12 / TWEAK Mouse anti-Human Monoclonal (Mira-2) Antibody
Human
ELISA, Flo, IP
Unconjugated
100 µg/$560
TNFSF12 / TWEAK Antibody - Sandwich ELISA of TWEAK antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TNFSF12 / TWEAK Goat anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
TNFSF12 / TWEAK Antibody - Sandwich ELISA of TWEAK antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TNFSF12 / TWEAK Goat anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
TNFSF12 / TWEAK Antibody - Anti-TNFSF12 / TWEAK antibody IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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TNFSF12 / TWEAK Rabbit anti-Human Polyclonal (Pro73) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
TNFSF12 / TWEAK Antibody - Anti-TNFSF12 / TWEAK antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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TNFSF12 / TWEAK Rabbit anti-Human Polyclonal (aa41-90) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
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TNFSF12 / TWEAK Goat anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$848
TNFSF12 / TWEAK Antibody - Immunohistochemistry of TWEAK in human brain tissue with TWEAK antibody at 10 ug/ml.
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TNFSF12 / TWEAK Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
TNFSF12 / TWEAK Antibody - Western blot of HUVEC,Jurkat and 293 cell lysate using TNFSF12 Antibody
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TNFSF12 / TWEAK Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
TNFSF12 / TWEAK Antibody - 1:100 staining human pancreas tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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TNFSF12 / TWEAK Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
TNFSF12 / TWEAK Antibody - 1:100 staining mouse testis tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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TNFSF12 / TWEAK Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
TNFSF12 / TWEAK Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TNFSF12 / TWEAK Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
TNFSF12 / TWEAK Antibody - Immunohistochemistry of paraffin-embedded human pancreatic tissue using antibody at dilution of 1:100.
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TNFSF12 / TWEAK Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
Select
TNFSF12 / TWEAK Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
TNFSF12 / TWEAK Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
TNFSF12 / TWEAK Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
TNFSF12 / TWEAK Antibody - Western blot of TWEAK antibody
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TNFSF12 / TWEAK Rabbit anti-Human Polyclonal (10-90 aa, Internal) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TNFSF12 / TWEAK Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using TNF12 antibody.
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TNFSF12 / TWEAK Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
Select
TNFSF12 / TWEAK Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
100 µl/$386
Select
TNFSF12 / TWEAK Mouse anti-Human Monoclonal (Low Endotoxin) (CARL-1) Antibody
Human
Flo, Func, IHC
Unconjugated, Low Endotoxin
0.1 mg/$302
Select
TNFSF12 / TWEAK Mouse anti-Human Monoclonal (CARL-1) Antibody
Human
Flo, Func, IHC
Unconjugated
0.1 mg/$302
Select
TNFSF12 / TWEAK Mouse anti-Human Monoclonal (PE) (CARL-1) Antibody
Human
Flo, Func, IHC
PE Conjugated
100 Tests/$365
TNFSF12 / TWEAK Antibody - Immunohistochemistry of paraffin-embedded human prostate using antibody at 1:100 dilution.
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TNFSF12 / TWEAK Rabbit anti-Human Polyclonal (aa42-123) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
Select
TNFSF12 / TWEAK Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
Select
TNFSF12 / TWEAK Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TNFSF12 / TWEAK Antibody - Western blot - Anti-TWEAK Picoband antibody
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TNFSF12 / TWEAK Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).