TNFSF11 / RANKL / TRANCE

tumor necrosis factor (ligand) superfamily, member 11

TNFSF11 / RANKL / TRANCE is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

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Products

ELISA Kits (34)

Type

Cell-Based (1)

Development Kit (4)

Sandwich (23)

Sandwich CLIA (6)

Target

TNFSF11 / RANKL / TRANCE (34)

Reactivity

Human (10)

Mouse (11)

Rat (10)

Dog (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Product Group

DevKit Core (2)

DevKit DuoPlus (2)

Format

1000 Wells (2)

12 x 8-Well Microstrips (4)

96-Well Microplate (6)

96-Well Strip Plate (20)

Antibody Pair and Standard (2)

Publications

No (34)

Sample Type

Adherent Cell Cultures (1)

Cell Culture Supernatants (14)

Cell Lysates (9)

Plasma (30)

Serum (30)

Tissue Homogenates (12)

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Human TNFSF11 / RANKL / TRANCE (Sandwich ELISA) ELISA Kit - LS-F2712

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum

Price:

1 Plate/$559

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Mouse TNFSF11 / RANKL / TRANCE (Sandwich ELISA) ELISA Kit - LS-F297

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

4 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$534

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Human TNFSF11 / RANKL / TRANCE (Sandwich ELISA) ELISA Kit - LS-F5672

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

3.12 - 200 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$764

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Rat TNFSF11 / RANKL / TRANCE (Sandwich ELISA) ELISA Kit - LS-F5673

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

15.63 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$715

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Mouse TNFSF11 / RANKL / TRANCE (Sandwich ELISA) ELISA Kit - LS-F5674

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$782

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Rat TNFSF11 / RANKL / TRANCE (Sandwich ELISA) ELISA Kit - LS-F23228

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

15.63 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Mouse/Human TNFSF11 / RANKL / TRANCE (Cell-Based ELISA) ELISA Kit - LS-F3001

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Rat TNFSF11 / RANKL / TRANCE (Sandwich ELISA) ELISA Kit - LS-F12790

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

7.8 - 500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$585

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Monkey TNFSF11 / RANKL / TRANCE (Sandwich ELISA) ELISA Kit - LS-F49257

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Mouse TNFSF11 / RANKL / TRANCE (Sandwich ELISA) ELISA Kit - LS-F2713

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$699

Select

Human TNFSF11 / RANKL / TRANCE (Sandwich ELISA) ELISA Kit - LS-F24426

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$632

Select

Mouse TNFSF11 / RANKL / TRANCE (Sandwich ELISA) ELISA Kit - LS-F24752

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$582

Select

Rat TNFSF11 / RANKL / TRANCE (CLIA) ELISA Kit - LS-F26423

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

2.74 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$911

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Rat TNFSF11 / RANKL / TRANCE (Sandwich ELISA) ELISA Kit - LS-F39872

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum

Price:

1 Plate/$699

Select

Rabbit TNFSF11 / RANKL / TRANCE (Sandwich ELISA) ELISA Kit - LS-F47634

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

0.16 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Mouse TNFSF11 / RANKL / TRANCE (Sandwich ELISA) ELISA Kit - LS-F56347

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Dog TNFSF11 / RANKL / TRANCE (Sandwich ELISA) ELISA Kit - LS-F54890

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Dog

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$748

Select

Rat TNFSF11 / RANKL / TRANCE (Sandwich ELISA) ELISA Kit - LS-F55851

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

DevKit DuoPlus Rat TNFSF11 / RANKL / TRANCE ELISA Development Kit - LS-F71909

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Rat

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

500 Wells/$1,254; 1000 Wells/$1,867

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DevKit DuoPlus Human TNFSF11 / RANKL / TRANCE ELISA Development Kit - LS-F71559

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

500 Wells/$1,182; 1000 Wells/$1,747

Select

Mouse TNFSF11 / RANKL / TRANCE (Sandwich ELISA) ELISA Kit - LS-F12791

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$585

Select

Human TNFSF11 / RANKL / TRANCE (Sandwich ELISA) ELISA Kit - LS-F12792

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

Select

Mouse TNFSF11 / RANKL / TRANCE (Sandwich ELISA) ELISA Kit - LS-F23074

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Human TNFSF11 / RANKL / TRANCE (CLIA) ELISA Kit - LS-F26042

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

41.15 - 30000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$851

Select

Human TNFSF11 / RANKL / TRANCE (Sandwich ELISA) ELISA Kit - LS-F37196

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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