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TNFSF10 / TRAIL
tumor necrosis factor (ligand) superfamily, member 10
TNFSF10 / TRAIL is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | tumor necrosis factor (ligand) superfamily, member 10 |
| Family/Subfamily: | TNF , not assigned-TNF |
| Synonyms: | TNFSF10, Apo-2L, APO2L, Apo-2 ligand, CD253, CD253 antigen, TRAIL, Protein TRAIL, TL2 |
| Target Sequences: | NM_003810 NP_003801.1 P50591 |
Publications (2)
1
IFN-alpha-induced apoptosis in hepatocellular carcinoma involves promyelocytic leukemia protein and TRAIL independently of p53. Herzer K, Hofmann TG, Teufel A, Schimanski CC, Moehler M, Kanzler S, Schulze-Bergkamen H, Galle PR. Cancer research. 2009 69:855-62.
[PubMed:19141642]
2
TRAIL Mediates Neuronal Death in AUD: A Link between Neuroinflammation and Neurodegeneration. Liya Qin, Jian Zou, Alexandra Barnett, Ryan P Vetreno, Fulton T Crews, Leon G Coleman Jr. International journal of molecular sciences. 2021 March;22:2547. [Full Text Article]
[PubMed:33806288]
[PMC:PMC7961445]
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Antibodies
(123)
Type
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(123)
Target
TNFSF10 / TRAIL
(123)
Reactivity
Human
(105)
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(25)
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(16)
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(11)
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(3)
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(17)
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(1)
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(6)
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(95)
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(14)
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(31)
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(4)
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(2)
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(8)
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(2)
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rabbit
(80)
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(38)
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(5)
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(3)
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(43)
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(11)
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(8)
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(8)
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(4)
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monoclonal mc
(43)
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(80)
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101
(1)
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(1)
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(7)
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(14)
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(5)
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(5)
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(11)
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(10)
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(2)
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(9)
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(1)
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(62)
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(18)
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(8)
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(8)
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(8)
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(4)
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(4)
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(3)
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(2)
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(1)
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(1)
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(1)
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(1)
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(1)
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(1)
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(1)
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(1)
Publications
No
(123)
TNFSF10 / TRAIL Rabbit anti-Human Polyclonal (1-80 aa, Internal) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TNFSF10 / TRAIL Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
500 µg/$326
TNFSF10 / TRAIL Mouse anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
500 µg/$533
TNFSF10 / TRAIL Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
100 µl/$763
TNFSF10 / TRAIL Mouse anti-Human Monoclonal (aa114-281) Antibody
Human
WB
Unconjugated
100 µl/$292; 200 µl/$327; 500 µl/$443; 1 ml/$501; 2 ml/$626; 5 ml/$1,072
TNFSF10 / TRAIL Mouse anti-Human Monoclonal (aa95-281) (366G/76/3) Antibody
Human
Flo, WB
Unconjugated
100 µg/$860; 500 µg/$1,223
TNFSF10 / TRAIL Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
TNFSF10 / TRAIL Rabbit anti-Human Polyclonal (aa31-80) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
TNFSF10 / TRAIL Rabbit anti-Human Polyclonal (C-terminal) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
TNFSF10 / TRAIL Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IHC, IHC-Fr, IP, WB
Unconjugated
100 µg/$629
TNFSF10 / TRAIL Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$485
TNFSF10 / TRAIL Mouse anti-Human Monoclonal (aa95-281) (Low Endotoxin) (2E5) Antibody
Human
Flo, WB
Unconjugated, Low Endotoxin
0.5 mg/$869
TNFSF10 / TRAIL Rabbit anti-Human Polyclonal (aa 39-281) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
TNFSF10 / TRAIL Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
TNFSF10 / TRAIL Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TNFSF10 / TRAIL Rat anti-Mouse Monoclonal Antibody
Mouse
Flo
Unconjugated
100 µg/$587
TNFSF10 / TRAIL Mouse anti-Human Monoclonal (RIK-2) Antibody
Human
Flo
Unconjugated
100 µg/$292
TNFSF10 / TRAIL Mouse anti-Human Monoclonal (aa17-35) (55B709.3) Antibody
Human
WB
Unconjugated
0.1 mg/$386
TNFSF10 / TRAIL Rabbit anti-Human Polyclonal (Ser63) Antibody
Human
IF, IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
TNFSF10 / TRAIL Rabbit anti-Human Polyclonal (aa261-277) Antibody
Human
ICC, IHC, WB
Unconjugated
100 µg/$522
TNFSF10 / TRAIL Rabbit anti-Human Polyclonal Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
TNFSF10 / TRAIL Mouse anti-Human Monoclonal (Preservative Free) (101) Antibody
Human
ICC, IF
Unconjugated, Preservative Free
100 µl/$412
TNFSF10 / TRAIL Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$357
TNFSF10 / TRAIL Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
100 µl/$412
TNFSF10 / TRAIL Rabbit anti-Mouse Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
Viewing 1-25
of 123
product results
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