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TNFRSF9 / 4-1BB / CD137

tumor necrosis factor receptor superfamily, member 9

TNFRSF9 / 4-1BB / CD137 is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.

Gene Name: tumor necrosis factor receptor superfamily, member 9
Family/Subfamily: TNF Receptor , not assigned-TNF Receptor
Synonyms: TNFRSF9, 4-1BB ligand receptor, 4-1BB, CD137 antigen, CD137, Homolog of mouse 4-1BB, ILA, Receptor protein 4-1BB, T cell antigen ILA, T-cell antigen 4-1BB homolog, T-cell antigen ILA, CDw137
Target Sequences: NM_001561 NP_001552.2 Q07011

Publications (2)

1
Progression of benign prostatic hyperplasia is associated with pro-inflammatory mediators and chronic activation of prostate-infiltrating lymphocytes. Norström MM, Rådestad E, Sundberg B, Mattsson J, Henningsohn L, Levitsky V, Uhlin M. Oncotarget. 2016 7:23581-93. (Flo, ELISA; Human) [Full Text Article] [PubMed:26993768] [PMC:PMC5029649]
2
CD137 (4-1BB) Engagement Fine-Tunes Synergistic IL-15- and IL-21-Driven NK Cell Proliferation. Laurent Vidard, Christine Dureuil, Jérémy Baudhuin, Lionel Vescovi, Laurence Durand, Véronique Sierra, Eric Parmantier. Journal of immunology (Baltimore, Md. : 1950). 2019 August;203:676-685. [Full Text Article] [PubMed:31201235]

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Antibodies (101)
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TNFRSF9 / 4-1BB / CD137 (148)
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TNFRSF9 / 4-1BB / CD137 Antibody - Immunofluorescent analysis of CD137 staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
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TNFRSF9 / 4-1BB / CD137 Rabbit anti-Human Polyclonal (aa89-118) Antibody
Mouse, Human, Monkey
ICC, IF, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
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TNFRSF9 / 4-1BB / CD137 Mouse anti-Human Monoclonal (Azide-free) (4B4-1) Antibody
Human
ELISA, Flo, Func
Unconjugated, Azide-free
100 µg/$446
TNFRSF9 / 4-1BB / CD137 Antibody - PHA-stimulated (3 days) human peripheral blood mononuclear cells stained with purified 4B4-1, followed by biotinylated anti-mouse IgG and Sav-PE
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TNFRSF9 / 4-1BB / CD137 Mouse anti-Human Monoclonal (4B4-1) Antibody
Human, Monkey, Baboon
ELISA, Flo, IP
Unconjugated
100 µg/$296
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TNFRSF9 / 4-1BB / CD137 Hamster anti-Mouse Monoclonal (Low Endotoxin) (ATM-2) Antibody
Mouse
Flo, Func
Unconjugated, Low Endotoxin
100 µg/$543; 500 µg/$629; 1 mg/$763
TNFRSF9 / 4-1BB / CD137 ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Human
16 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$414
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TNFRSF9 / 4-1BB / CD137 Rat anti-Human Monoclonal (JG1.6A) Antibody
Human
ELISA, Flo
Unconjugated
25 µg/$281; 0.2 mg/$471
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Mammalian Cells
6His, C-terminus
Less than 0.1 ng/mL (Less than 1 EU/µg) (determined by LAL method).
10 µg/$266; 50 µg/$339; 500 µg/$1,010; 1 mg/$1,329
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TNFRSF9 / 4-1BB / CD137 Mouse anti-Human Monoclonal (4G10B9) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
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TNFRSF9 / 4-1BB / CD137 Mouse anti-Human Monoclonal (PE) Antibody
Human
Flo, IF
PE Conjugated
100 µl/$1,104
TNFRSF9 / 4-1BB / CD137 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TNFRSF9 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TNFRSF9.
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TNFRSF9 / 4-1BB / CD137 Mouse anti-Human Monoclonal (OTI5H5) Antibody
Human
WB
Unconjugated
100 µl/$434
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TNFRSF9 / 4-1BB / CD137 Goat anti-Human Polyclonal (Extracellular Domain) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
100 µg/$962
TNFRSF9 / 4-1BB / CD137 Protein
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E. coli
None
Biologically active
17.7 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
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CHO Cells
Human IgG1 Fc
Biologically active
Less than 0.06 EU/µg protein (determined by LAL method).
100 µg/$463
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TNFRSF9 / 4-1BB / CD137 Goat anti-Human Polyclonal (Extracellular Domain) (Biotin) Antibody
Human
ELISA, Flo, ICC, WB
Biotin Conjugated
50 µg/$1,054
TNFRSF9 / 4-1BB / CD137 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY TNFRSF9. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TNFRSF9. (1:500)
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TNFRSF9 / 4-1BB / CD137 Mouse anti-Human Monoclonal (OTI4G1) Antibody
Human
Flo, WB
Unconjugated
100 µl/$434
TNFRSF9 / 4-1BB / CD137 Antibody - Fig-2: Immunohistochemical analysis of CD137. Anti-CD137 was used in Human Brain tissue at 2 µg/ml.
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TNFRSF9 / 4-1BB / CD137 Mouse anti-Human Monoclonal Antibody
Human
IHC, WB
Unconjugated
25 µg/$288; 100 µg/$414
TNFRSF9 / 4-1BB / CD137 Antibody - Flow cytometry of TNFRSF9 / 4-1BB / CD137 antibody
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TNFRSF9 / 4-1BB / CD137 Mouse anti-Human Monoclonal (4B4-1) Antibody
Human
ELISA, Flo, Func
Unconjugated
100 µg/$446
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TNFRSF9 / 4-1BB / CD137 Mouse anti-Human Monoclonal (Biotin) (4B4-1) Antibody
Human
Flo, IHC
Biotin Conjugated
100 µg/$763
TNFRSF9 / 4-1BB / CD137 Antibody - Immunohistochemistry of paraffin-embedded Human gastric cancer using TNFRSF9 Polyclonal Antibody at dilution of 1:40.
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TNFRSF9 / 4-1BB / CD137 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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TNFRSF9 / 4-1BB / CD137 Mouse anti-Human Monoclonal (4B4-1) Antibody
Human
Flo
Unconjugated
100 µg/$626
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TNFRSF9 / 4-1BB / CD137 Goat anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$860
TNFRSF9 / 4-1BB / CD137 Antibody
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TNFRSF9 / 4-1BB / CD137 Rabbit anti-Human Polyclonal (aa40-153) (APC) Antibody
Rat, Pig, Human
WB
APC Conjugated
100 µl/$396; 200 µl/$476; 500 µl/$815; 1 ml/$969; 2 ml/$1,240; 5 ml/$2,325
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TNFRSF9 / 4-1BB / CD137 Mouse anti-Human Monoclonal (Low Endotoxin) (4B4-1) Antibody
Human, Non-Human Primates
ELISA, Flo, Func, IP
Unconjugated, Low Endotoxin
0.1 mg/$302
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TNFRSF9 / 4-1BB / CD137 Mouse anti-Human Monoclonal (4B4-1) Antibody
Human, Non-Human Primates
ELISA, Flo, Func, IP
Unconjugated
0.1 mg/$302
TNFRSF9 / 4-1BB / CD137 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
12.29 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$760
Viewing 1-25 of 148 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).