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TNFRSF19 / TROY is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Gene Name: | tumor necrosis factor receptor superfamily, member 19 |
Family/Subfamily: | TNF Receptor , not assigned-TNF Receptor |
Synonyms: | TNFRSF19, TAJ-alpha, TRADE, TROY, Toxicity and JNK inducer, TAJ |
Target Sequences: | NM_018647 NP_061117.2 Q9NS68 |
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