Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart Cart lightblue
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Location


Corporate Headquarters

Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States

Telephone Numbers



Customer Service: (800) 227-6666 / (650) 697-3600


Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

TNFRSF11A / RANK

tumor necrosis factor receptor superfamily, member 11a, NFKB activator

TNFRSF11A / RANK is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.

Gene Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Family/Subfamily: TNF Receptor , not assigned-TNF Receptor
Synonyms: TNFRSF11A, CD265, CD265 antigen, ODFR, LOH18CR1, OPTB7, OSTS, PDB2, RANK, Receptor activator of NF-KB, TRANCER, FEO, OFE
Target Sequences: NM_003839 NP_003830.1 Q9Y6Q6

Publications (2)

1
Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation. Yugo Morita, Motoo Saito, Javier Rangel-Moreno, Anthony M Franchini, John R Owen, John C Martinez, John L Daiss, Karen L de Mesy Bentley, Stephen L Kates, Edward M Schwarz, Gowrishankar Muthukrishnan. Bone research. 2022 August;10:56. [Full Text Article] [PubMed:36028492] [PMC:PMC9418173] Related Antibodies: LS-B2077.
2
Granulomatous Inflammation and Hypercalcemia in Patients With Severe Systemic Oxalosis. Peggy Perrin, Jérome Olagne, Arnaud Delbello, Stanislas Bataille, Laurent Mesnard, Claire Borni, Bruno Moulin, Sophie Caillard. Kidney international reports. 2022 February;7:343-349. [Full Text Article] [PubMed:35155875] [PMC:PMC8820998] Related Antibodies: LS-B11252.

☰ Filters
Products
Proteins (19)
Over-Expression Lysate (2)
Recombinant (17)
TNFRSF11A / RANK (19)
No (19)
6His, C-terminus (4)
6His, N-terminus (1)
Fc (1)
GST, N-terminus (1)
His (1)
His, N-Terminal (1)
His,C-terminus (1)
His-T7 (2)
Human IgG1 Fc (2)
Myc-DDK (Flag) (2)
Human (11)
Mouse (4)
Rat (3)
293T Cells (1)
E. coli (7)
HEK 293 Cells (5)
Human Cells (3)
Mammalian Cells (2)
Wheat Germ Extract (1)
Purified (5)
Low endotoxin level (10)
Biologically active (3)
TNFRSF11A / RANK Protein - Recombinant Receptor Activator Of Nuclear Factor Kappa B By SDS-PAGE
Select
E. coli
His, N-Terminal
30.0 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
Select
HEK 293 Cells
Human IgG1 Fc
Less than 0.01 EU/µg protein (determined by LAL method).
~55kDa (SDS-PAGE)
50 µg/$351
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
19.3 kDa
20 µg/$268; 100 µg/$349
TNFRSF11A / RANK Protein
Select
E. coli
None
Biologically active
19.1 kDa
100 µg/$425; 500 µg/$789
TNFRSF11A / RANK Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
TNFRSF11A / RANK Protein - Recombinant Receptor Activator Of Nuclear Factor Kappa B By SDS-PAGE
Select
E. coli
His-T7
33.8 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
TNFRSF11A / RANK Protein - Recombinant Receptor Activator Of Nuclear Factor Kappa B By SDS-PAGE
Select
E. coli
His-T7
24.0 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
Select
E. coli
His
23.3 kD
100 µg/$420; 20 µg/$323; 1 mg/$1,355
TNFRSF11A / RANK Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
66.03 kDa
20 µg/$215
TNFRSF11A / RANK Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
66.03 kDa
100 µg/$710
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
47.1 kDa
100 µg/$502
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.5 kDa
100 µg/$502
TNFRSF11A / RANK Protein - RANK inhibits osteoclast differentiation induced by human RANKL on RAW246.7 murine macrophages.
Select
HEK 293 Cells
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 191 amino acid recombinant protein has a predicted molecular mass of approximately 47.8 kD. The protein migrates at approximately 60 kD in DTT-reduced conditions and at approximately 120 kD in non-reduced conditions by SDS-PAGE. The predicted N-termin
25 µg/$306; 100 µg/$375
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.1 kDa
10 µg/$277; 50 µg/$389
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.3 kDa
10 µg/$281; 50 µg/$389
Select
HEK 293 Cells
Human IgG1 Fc
Less than 0.01 EU/µg protein (determined by LAL method).
~55kDa (SDS-PAGE)
50 µg/$379
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.3kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.1kD
10 µg/$277; 50 µg/$395; 500 µg/$1,203; 1 mg/$1,627
TNFRSF11A / RANK Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Select
E. coli
6His, N-terminus
20 kDa
10 µg/$265; 50 µg/$315; 200 µg/$484
Viewing 1-19 of 19 product results


Filtered By:
Products: Proteins


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).