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Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
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Customer Service: (800) 227-6666 / (650) 697-3600
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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
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TNFRSF10B / Killer / DR5
tumor necrosis factor receptor superfamily, member 10b
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.
| Gene Name: | tumor necrosis factor receptor superfamily, member 10b |
| Family/Subfamily: | TNF Receptor , not assigned-TNF Receptor |
| Synonyms: | TNFRSF10B, Cytotoxic TRAIL receptor-2, CD262 antigen, DR5, Death receptor 5, KILLER, TRAIL-R2, TRICK2B, TRAILR2, TRICK2A, TRICKB, TRICK2, CD262, Fas-like protein, TRAIL receptor 2, ZTNFR9 |
| Target Sequences: | NM_147187 Q6FH58 O14763 |
Publications (3)
1
Multimeric Anti-DR5 IgM Agonist Antibody IGM-8444 Is a Potent Inducer of Cancer Cell Apoptosis and Synergizes with Chemotherapy and BCL-2 Inhibitor ABT-199. Beatrice T Wang, Tasnim Kothambawala #, Ling Wang #, Thomas J Matthew #, Susan E Calhoun, Avneesh K Saini, Maya F Kotturi, Genevive Hernandez, Eric W Humke, Marvin S Peterson, Angus M Sinclair, Bruce A Keyt. The Breast : official journal of the European Society of Mastology. 2021 Dec;;20:2483-2494. [Full Text Article]
[PubMed:34711645]
Related Antibodies: LS-C340229.
2
Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma. Shi J, Tricot GJ, Garg TK, Malaviarachchi PA, Szmania SM, Kellum RE, Storrie B, Mulder A, Shaughnessy JD, Barlogie B, van Rhee F. Blood. 2008 111:1309-17.
[PubMed:17947507]
[PMC:PMC2214736]
Related Antibodies: LS-C40990.
3
Bortezomib and depsipeptide sensitize tumors to tumor necrosis factor-related apoptosis-inducing ligand: a novel method to potentiate natural killer cell tumor cytotoxicity. Lundqvist A, Abrams SI, Schrump DS, Alvarez G, Suffredini D, Berg M, Childs R. Cancer research. 2006 66:7317-25.
[PubMed:16849582]
Related Antibodies: LS-C40991.
☰ Filters
Products
Proteins
(28)
Type
Over-Expression Lysate
(4)
Recombinant
(24)
Target
TNFRSF10B / Killer / DR5
(28)
Publications
No
(28)
Tag
6His, C-terminus
(3)
6His, N-terminus
(1)
Fc, C-terminus
(3)
Fc/6His,C-terminus
(1)
Fc/His,C-terminus
(1)
Fc-6His, C-terminus
(2)
GST, N-terminus
(1)
His
(2)
His-AVI, C-terminus
(1)
His-GST
(1)
His-GST, N-terminus
(1)
Human IgG1 Fc
(1)
Myc-DDK (Flag)
(5)
Species
Human
(18)
Mouse
(8)
Source
293T Cells
(2)
E. coli
(9)
HEK 293 Cells
(5)
Human Cells
(4)
Mammalian Cells
(7)
Wheat Germ Extract
(1)
Purification
Purified
(4)
Low Endotoxin Level
Low endotoxin level
(17)
Biologically Active
Biologically active
(8)
E. coli
6His, N-terminus
15.6 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
14.9 kDa
10 µg/$268; 50 µg/$349
E. coli
None
Biologically active
14.8 kDa
10 µg/$282; 100 µg/$503; 500 µg/$1,058
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
15.19kD
10 µg/$240; 50 µg/$299; 500 µg/$929; 1 mg/$1,245
Human Cells
Fc-6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.2kD
10 µg/$248; 50 µg/$321; 500 µg/$785; 1 mg/$1,021
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
40.9kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
293T Cells
Myc-DDK (Flag)
47.87 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
39.4 kDa
20 µg/$150
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
15 kDa
100 µg/$661; 1 mg/$3,499
HEK 293 Cells
Myc-DDK (Flag)
39.4 kDa
100 µg/$494
HEK 293 Cells
Myc-DDK (Flag)
39.4 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
47.87 kDa
100 µg/$494
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
14.8 kDa
10 µg/$278; 1 mg/$1,470; 50 µg/$364
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~15 kDa
200 µg/$537; 1 mg/$1,526
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~15 kDa
50 µg/$310
Mammalian Cells
Fc-6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
42.2 kDa
50 µg/$356; 10 µg/$259; 1 mg/$1,261; 500 µg/$1,025
Mammalian Cells
6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
15.19 kDa
50 µg/$327; 10 µg/$250; 1 mg/$1,518; 500 µg/$1,170
Mammalian Cells
Fc, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
40.9 kDa
50 µg/$453; 10 µg/$303; 1 mg/$2,837; 500 µg/$1,987
Mammalian Cells
Fc/6His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.2 kDa
10 µg/$248; 50 µg/$317
HEK 293 Cells
Fc/His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.8 kDa
100 µg/$661
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
15.2 kDa
10 µg/$240; 50 µg/$299
Mouse TNFRSF10B / Killer / DR5 Protein (Recombinant His-AVI, C-terminus) (Asn53-Ser177) - LS-G138375
Mammalian Cells
His-AVI, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
16.4 kDa
20 µg/$416; 100 µg/$910
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
40.9 kDa
10 µg/$281; 50 µg/$389
E. coli
His-GST, N-terminus
53kDa
10 µg/$318; 50 µg/$672; 200 µg/$1,256; 100 µg/$1,057; 1 mg/$2,507; 500 µg/$2,007; 5 mg/$4,691; 2 mg/$2,699
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