Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
Products
Antibodies
ELISA and Assay Kits
Research Areas
Infectious Disease
Resources
Purchasing
Reference Material
Contact Us
Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
Contact Us
Additional Contact Details
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
TNFRSF10B / Killer / DR5
tumor necrosis factor receptor superfamily, member 10b
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.
| Gene Name: | tumor necrosis factor receptor superfamily, member 10b |
| Family/Subfamily: | TNF Receptor , not assigned-TNF Receptor |
| Synonyms: | TNFRSF10B, Cytotoxic TRAIL receptor-2, CD262 antigen, DR5, Death receptor 5, KILLER, TRAIL-R2, TRICK2B, TRAILR2, TRICK2A, TRICKB, TRICK2, CD262, Fas-like protein, TRAIL receptor 2, ZTNFR9 |
| Target Sequences: | NM_147187 Q6FH58 O14763 |
Publications (3)
1
Multimeric Anti-DR5 IgM Agonist Antibody IGM-8444 Is a Potent Inducer of Cancer Cell Apoptosis and Synergizes with Chemotherapy and BCL-2 Inhibitor ABT-199. Beatrice T Wang, Tasnim Kothambawala #, Ling Wang #, Thomas J Matthew #, Susan E Calhoun, Avneesh K Saini, Maya F Kotturi, Genevive Hernandez, Eric W Humke, Marvin S Peterson, Angus M Sinclair, Bruce A Keyt. The Breast : official journal of the European Society of Mastology. 2021 Dec;;20:2483-2494. [Full Text Article]
[PubMed:34711645]
Related Antibodies: LS-C340229.
2
Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma. Shi J, Tricot GJ, Garg TK, Malaviarachchi PA, Szmania SM, Kellum RE, Storrie B, Mulder A, Shaughnessy JD, Barlogie B, van Rhee F. Blood. 2008 111:1309-17.
[PubMed:17947507]
[PMC:PMC2214736]
Related Antibodies: LS-C40990.
3
Bortezomib and depsipeptide sensitize tumors to tumor necrosis factor-related apoptosis-inducing ligand: a novel method to potentiate natural killer cell tumor cytotoxicity. Lundqvist A, Abrams SI, Schrump DS, Alvarez G, Suffredini D, Berg M, Childs R. Cancer research. 2006 66:7317-25.
[PubMed:16849582]
Related Antibodies: LS-C40991.
☰ Filters
Products
Antibodies
(113)
Proteins
(28)
ELISA Kits
(6)
Type
Custom
(1)
Over-Expression Lysate
(4)
Primary
(113)
Recombinant
(24)
Sandwich
(5)
Target
TNFRSF10B / Killer / DR5
(147)
Reactivity
Human
(98)
Mouse
(29)
Rat
(5)
Monkey
(2)
Application
IHC
(22)
IHC-P
(11)
WB
(82)
Flo
(23)
ELISA
(28)
Func
(3)
ICC
(12)
IF
(2)
IP
(11)
Peptide-ELISA
(1)
Host
rabbit
(74)
mouse
(38)
goat
(1)
Product Group
IHCPlus
(5)
Isotype
IgG
(34)
IgG1
(26)
IgG1,k
(6)
IgG2a
(1)
Clonality
monoclonal mc
(37)
polyclonal pc
(76)
Clone
2H5B8
(1)
DJR2-2 (2-6)
(1)
DJR2-4 (7-8)
(1)
DR5-01
(1)
DR5-01-1
(6)
HS201
(6)
OTI1B9
(2)
OTI2A5
(2)
OTI4B12
(2)
OTI5G5
(2)
TR2.21
(1)
TS106
(1)
Format
96-Well Microplate
(1)
96-Well Strip Plate
(5)
APC
(3)
APC Conjugated
(6)
Atto 488 Conjugated
(1)
Atto 647N Conjugated
(1)
Azide-free
(1)
Biotin Conjugated
(10)
Carrier-free
(4)
Concentrated
(1)
Cy3 Conjugated
(3)
Cy7 Conjugated
(3)
FITC Conjugated
(11)
HRP Conjugated
(9)
PE Conjugated
(8)
Preservative Free
(2)
Unconjugated
(61)
Epitope
aa203-411
(8)
aa233-367
(8)
aa234-435
(8)
aa54-180
(8)
Extracellular Domain
(7)
aa38-87
(4)
Internal
(3)
aa388-407
(2)
N-Terminus
(1)
aa333-348
(1)
aa417-436
(1)
aa56-128
(1)
aa71-170
(1)
Publications
No
(144)
Yes
(3)
Sample Type
Cell Culture Supernatants
(1)
Cell Lysates
(2)
Plasma
(4)
Serum
(4)
Tissue Homogenates
(2)
Tag
6His, C-terminus
(3)
6His, N-terminus
(1)
Fc, C-terminus
(3)
Fc/6His,C-terminus
(1)
Fc/His,C-terminus
(1)
Fc-6His, C-terminus
(2)
GST, N-terminus
(1)
His
(2)
His-AVI, C-terminus
(1)
His-GST
(1)
His-GST, N-terminus
(1)
Human IgG1 Fc
(1)
Myc-DDK (Flag)
(5)
Species
Human
(18)
Mouse
(8)
Source
293T Cells
(2)
E. coli
(9)
HEK 293 Cells
(5)
Human Cells
(4)
Mammalian Cells
(7)
Wheat Germ Extract
(1)
Purification
Purified
(4)
Low Endotoxin Level
Low endotoxin level
(17)
Biologically Active
Biologically active
(8)
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (HS201) Antibody
Human
Flo, Func, ICC, IHC, IHC-P, IP
Unconjugated
50 µg/$460
TNFRSF10B / Killer / DR5 Rabbit anti-Human Polyclonal (aa388-407) Antibody
Human
Flo, ICC, IHC, IHC-P, WB
Unconjugated
50 µg/$460
TNFRSF10B / Killer / DR5 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (aa203-411) (OTI1B9) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (aa203-411) (Carrier-free) (OTI1B9) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TNFRSF10B / Killer / DR5 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µl/$332
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (HS201) Antibody
Human
Flo, Func, ICC, IHC, IHC-P, IP
Unconjugated
50 µg/$460
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (Extracellular Domain) (DJR2-2 (2-6)) Antibody
Human
Flo
Unconjugated
100 µg/$344
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal Antibody
Mouse, Human
ICC, WB
Unconjugated
100 µl/$391
TNFRSF10B / Killer / DR5 Rabbit anti-Mouse Polyclonal Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$460
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (Extracellular Domain) (DJR2-4 (7-8)) Antibody
Human
Flo
Unconjugated
100 µg/$344
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (TR2.21) Antibody
Human
Flo, IHC, IHC-P
Unconjugated
100 µg/$470
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (Extracellular Domain) (PE) (DR5-01-1) Antibody
Human
Flo
PE Conjugated
0.1 mg/$435
TNFRSF10B / Killer / DR5 Rabbit anti-Mouse Polyclonal (aa54-180) (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$392; 200 µl/$470; 500 µl/$798; 1 ml/$951; 2 ml/$1,211; 5 ml/$2,269
TNFRSF10B / Killer / DR5 Goat anti-Human Polyclonal (Extracellular Domain) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$556
TNFRSF10B / Killer / DR5 Rabbit anti-Human Polyclonal (aa417-436) (Azide-free) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated, Azide-free
100 µg/$386
TNFRSF10B / Killer / DR5 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
E. coli
6His, N-terminus
15.6 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (aa203-411) (OTI4B12) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (aa203-411) (Carrier-free) (OTI4B12) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (aa203-411) (OTI2A5) Antibody
Mouse, Human, Monkey
IHC, WB
Unconjugated
100 µl/$434
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (aa203-411) (Carrier-free) (OTI2A5) Antibody
Mouse, Human, Monkey
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (Biotin) (HS201) Antibody
Human
Flo, Func, ICC, IP
Biotin Conjugated
100 µg/$491
TNFRSF10B / Killer / DR5 Rabbit anti-Human Polyclonal (aa234-435) Antibody
Human
ICC, IP, WB
Unconjugated
100 µl/$299; 200 µl/$336; 500 µl/$462; 1 ml/$525; 2 ml/$677; 5 ml/$1,136
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (aa203-411) (Carrier-free) (OTI5G5) Antibody
Human
IHC
Unconjugated, Carrier-free
100 µg/$511
Viewing 1-25
of 147
product results
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
