Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
Products
Antibodies
ELISA and Assay Kits
Research Areas
Infectious Disease
Resources
Purchasing
Reference Material
Contact Us
Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
Contact Us
Additional Contact Details
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
TNF Alpha
tumor necrosis factor
TNF Alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
| Gene Name: | tumor necrosis factor |
| Family/Subfamily: | TNF , not assigned-TNF |
| Synonyms: | TNF, APC1 protein, Cachectin, DIF, TNF Alpha, Tumor necrosis factor-alpha, TNF-alpha, TNF-a, TNFA, Tumor necrosis factor, TNF, macrophage-derived, TNF, monocyte-derived, TNFSF2 |
| Target Sequences: | NM_000594 NP_000585.2 P01375 |
Publications (20)
1
Down-regulation of tumor necrosis factor alpha expression by activating transcription factor 2 increases UVC-induced apoptosis of late-stage melanoma cells. Ivanov VN, Ronai Z. The Journal of biological chemistry. 1999 274:14079-89.
[PubMed:10318823]
Related Antibodies: LS-C41024.
2
TNF-alpha drives human CD14+ monocytes to differentiate into CD70+ dendritic cells evoking Th1 and Th17 responses. Iwamoto S, Iwai S, Tsujiyama K, Kurahashi C, Takeshita K, Naoe M, Masunaga A, Ogawa Y, Oguchi K, Miyazaki A. Journal of immunology (Baltimore, Md. : 1950). 2007 179:1449-57.
[PubMed:17641010]
Related Antibodies: LS-C41025.
3
Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving. Varadarajan N, Kwon DS, Law KM, Ogunniyi AO, Anahtar MN, Richter JM, Walker BD, Love JC. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:3885-90.
[PubMed:22355106]
[PMC:PMC3309713]
Related Antibodies: LS-C41024.
☰ Filters
Products
Proteins
(99)
Type
Over-Expression Cell Culture Supernatant
(1)
Over-Expression Lysate
(3)
Recombinant
(94)
Target
TNF Alpha
(99)
Application
SDS-PAGE
(3)
Product Group
Coronavirus Antibodies Proteins cDNAs
(99)
Cytokine Release Syndrome
(99)
Cytokine Release Syndrome Proteins
(99)
Format
Animal-free
(2)
Publications
No
(99)
Tag
10His, N-terminus
(1)
6His, C-terminus
(4)
6His, N-terminus
(6)
6His-B2M, N-terminus
(1)
6His-SUMO, N-terminus
(1)
DDK (Flag)
(1)
DDK (Flag)-Human ACRP30headless aa 16-108
(1)
DDK,N-terminus
(1)
GST
(1)
GST, N-terminus
(2)
His
(6)
His, N-Terminal
(7)
His,C-terminus
(1)
His-DDK (Flag), N-terminus
(1)
His-GST
(1)
His-T7
(7)
Human IgG1 Fc, N-terminus
(1)
Myc-DDK (Flag)
(3)
Species
Bovine
(3)
Chicken
(1)
Dog
(3)
Horse
(2)
Human
(40)
Mouse
(21)
Pig
(6)
Rabbit
(4)
Rat
(10)
Rhesus monkey
(1)
Sheep
(3)
Woodchuck
(2)
Source
293F Cells
(2)
293T Cells
(1)
Baculovirus
(1)
CHO Cells
(1)
E. coli
(70)
HEK 293 Cells
(8)
Wheat Germ Extract
(2)
Yeast
(7)
Purification
Purified
(37)
Supernatant
(1)
Low Endotoxin Level
Low endotoxin level
(47)
Biologically Active
Biologically active
(39)
Animal-free
Animal-free
(2)
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.4 kDa
10 µg/$268; 50 µg/$349
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
10 µg/$282; 50 µg/$369
E. coli
DDK (Flag)
Biologically active
Less than 0.01 EU/µg protein (determined by LAL method).
~17kDa (SDS-PAGE)
50 µg/$337; 10 µg/$267
E. coli
His-GST
38.1 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
Wheat Germ Extract
GST, N-terminus
51.37 kDa
10 µg/$479; 25 µg/$670
CHO Cells
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~18 kDa
50 µg/$790
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
17.3 kDa (SDS-PAGE)
50 µg/$304; 10 µg/$262; 1 mg/$990
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.3 kDa
5 µg/$268; 20 µg/$349
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
5 µg/$282; 20 µg/$370
293F Cells
His, N-Terminal
24kDa
10 µg/$315; 50 µg/$652; 200 µg/$1,228; 1 mg/$2,469; 5 mg/$4,551; 2 mg/$2,661
E. coli
His, N-Terminal
20kDa
10 µg/$275; 50 µg/$402; 200 µg/$802; 1 mg/$1,876; 5 mg/$2,838; 2 mg/$2,060
Yeast
His
19.2 kD
100 µg/$679; 20 µg/$429; 1 mg/$1,973
E. coli
6His, C-terminus
17 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.3 kDa
5 µg/$268; 20 µg/$349
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$317; 500 µg/$526; 20 µg/$245; 50 µg/$273; 250 µg/$429
E. coli
None
100 µg/$511; 500 µg/$1,355; 50 µg/$392; 10 µg/$286; 20 µg/$348; 250 µg/$872
E. coli
His
Biologically active
18.3 kDa
10 µg/$282; 100 µg/$503; 500 µg/$1,058
E. coli
None
Biologically active
16.9 kDa
10 µg/$282; 100 µg/$503; 500 µg/$1,058
E. coli
None
Biologically active
17.5 kDa
10 µg/$282; 100 µg/$503; 500 µg/$1,058
E. coli
None
Biologically active
17.4 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
E. coli
His-T7
21.0 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
E. coli
His-T7
21.0 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
His-T7
21.1 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
E. coli
His-T7
20.9 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
E. coli
His-T7
29.4 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
Viewing 1-25
of 99
product results
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
