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TMPRSS2 / Epitheliasin

transmembrane protease, serine 2

Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) , human coronavirus EMC (HCoV-EMC), SARS-CoV and SARS-CoV-2, and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.

Gene Name: transmembrane protease, serine 2
Family/Subfamily: Protease , Serine S1
Synonyms: TMPRSS2, Epitheliasin, PRSS10, Serine protease 10, PP9284, host protease for SARS-CoV-2 replication
Target Sequences: NM_005656 NP_005647.3 O15393

Publications (4)

1
Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity10<sup> Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Member of Fraunhofer International Consortium for Anti-Infective Research (iCAIR), Nikolai-Fuchs-Strasse 1, 30625 Hannover, Germany12<sup> Discovery Technology Rese. Markus Hoffmann, Heike Hofmann-Winkler, Joan C Smith, Nadine Krüger, Prerna Arora, Lambert K Sørensen, Ole S Søgaard, Jørgen Bo Hasselstrøm, Michael Winkler, Tim Hempel, Lluís Raich, Simon Olsson, Olga Danov, Danny Jonigk, Takashi Yamazoe, Katsura Yamatsuta, Hirotaka Mizuno, Stephan Ludwig, Frank Noé, Mads Kjolby, Armin Braun, Jason M Sheltzer, Stefan Pöhlmann. EBioMedicine. 2021 Mar;;65:103255. [Full Text Article] [PubMed:33676899] [PMC:PMC7930809]
2
Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry. bioRxiv : the preprint server for biology. 2021 Jul; [Full Text Article] [PubMed:33821268] [PMC:PMC8020968]
3
Synergistic inhibition of SARS-CoV-2 cell entry by otamixaban and covalent protease inhibitors: pre-clinical assessment of pharmacological and molecular properties. Tim Hempel , Katarina Elez, Nadine Krüger, Lluís Raich, Jonathan H Shrimp, Olga Danov, Danny Jonigk , Armin Braun, Min Shen, Matthew D Hall, Stefan Pöhlmann , Markus Hoffmann , Frank Noé. Chemical science. 2021 Aug;12:12600-12609. [Full Text Article] [PubMed:34703545] [PMC:PMC8494051]
4
Identification of trypsin-degrading commensals in the large intestine. Youxian Li , Eiichiro Watanabe , Yusuke Kawashima , Damian R Plichta, Zhujun Wang, Makoto Ujike, Qi Yan Ang, Runrun Wu, Munehiro Furuichi, Kozue Takeshita, Koji Yoshida, Keita Nishiyama, Sean M Kearney, Wataru Suda, Masahira Hattori, Satoshi Sasajima, Takahiro Matsunaga, Xiaoxi Zhang, Kazuto Watanabe, Jun Fujishiro, Jason M Norman, Bernat Olle, Shutoku Matsuyama, Ho Namkoong, Yoshifumi Uwamino, Makoto Ishii, Koichi Fukunaga, Naoki Hasegawa, Osamu Ohara, Ramnik J Xavier, Koji Atarashi, Kenya Hond. Nature. 2022 September;609:582-589. [Full Text Article] [PubMed:36071157] [PMC:PMC9477747] Related Antibodies: LS-C373022.
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TMPRSS2 / Epitheliasin (54)
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TMPRSS2 / Epitheliasin Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
TMPRSS2 / Epitheliasin Antibody - Western blot of TMPRSS2 antibody in HepG2 cell line lysates (35 ug/lane). TMPRSS2 (arrow) was detected using the purified antibody.
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TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal (aa314-343) Antibody
Human
Flo, WB
Unconjugated
400 µl/$393
TMPRSS2 / Epitheliasin Antibody - Western blot of TMPRSS2 / Epitheliasin antibody.
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TMPRSS2 / Epitheliasin Rabbit anti-Mouse Polyclonal (aa254-490) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
TMPRSS2 / Epitheliasin Antibody - Western blot of TMPRSS2 / Epitheliasin antibody.
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TMPRSS2 / Epitheliasin Rabbit anti-Mouse Polyclonal (aa254-490) (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
TMPRSS2 / Epitheliasin Protein - 12.5% SDS-PAGE of human TMPRSS2 stained with Coomassie Blue
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Wheat Germ Extract
GST, N-terminus
79.86 kDa
2 µg/$439
TMPRSS2 / Epitheliasin ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
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TMPRSS2 / Epitheliasin Protein - Recombinant Transmembrane Protease, Serine 2 By SDS-PAGE
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E. coli
His,N-terminus
27.2 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
TMPRSS2 / Epitheliasin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$730
TMPRSS2 / Epitheliasin Antibody - Detection limit for recombinant GST tagged TMPRSS2 is approximately 3 ng/ml as a capture antibody.
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TMPRSS2 / Epitheliasin Mouse anti-Human Monoclonal (2F4) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
TMPRSS2 / Epitheliasin Antibody - Western blot of TMPS2 Antibody with human Fetal Liver lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Rabbit, Mouse, Bovine, Rat, Pig, Human
WB
FITC Conjugated
100 µl/$469
TMPRSS2 / Epitheliasin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TMPRSS2 / Epitheliasin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
53.7 kDa
20 µg/$150
TMPRSS2 / Epitheliasin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
53.7 kDa
100 µg/$494
TMPRSS2 / Epitheliasin Protein - Recombinant Transmembrane Protease, Serine 2 By SDS-PAGE
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E. coli
His-T7
29.6 kDa
10 µg/$282; 50 µg/$447; 100 µg/$715; 200 µg/$892; 1 mg/$2,005; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192
TMPRSS2 / Epitheliasin Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal (aa100-470) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
TMPRSS2 / Epitheliasin Antibody - Antibody (0.1 ug/ml) staining of Human Pancreas Lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence
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TMPRSS2 / Epitheliasin Goat anti-Human Polyclonal (Internal Region) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
TMPRSS2 / Epitheliasin Antibody - Western blot of recombinant TMPRSS2 / Epitheliasin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal (aa284-492) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
TMPRSS2 / Epitheliasin Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
TMPRSS2 / Epitheliasin ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
TMPRSS2 / Epitheliasin Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
TMPRSS2 / Epitheliasin Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Fast Shipping
TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$440
TMPRSS2 / Epitheliasin Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Fast Shipping
TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$440
Select
TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
Viewing 1-25 of 54 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).