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May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence.
Gene Name: | transmembrane protease, serine 11D |
Family/Subfamily: | Protease , Serine S1 |
Synonyms: | TMPRSS11D, Airway trypsin like protease, Airway tryptase, Airway trypsin-like protease, HAT |
Target Sequences: | NM_004262 NP_004253.1 O60235 |
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