TMED10 / TMP21

transmembrane emp24-like trafficking protein 10 (yeast)

Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

TMED10 / TMP21 (3)

Publications

No (3)

Tag

His (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

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Purified (1)

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Human TMED10 / TMP21 Protein (Recombinant His) - LS-G2474

Source:

E. coli

Tag:

His

Molecular Weight:

20 kDa

Price:

20 µg/$361; 100 µg/$739; 4 µg/$261

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Human TMED10 / TMP21 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76730

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.98 kDa

Price:

20 µg/$150

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TMED10 / TMP21 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100927

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.98 kDa

Price:

100 µg/$494

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