TLR8

toll-like receptor 8

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Like TLR7, TLR8 is localized to endosomal or lysosomal compartments and stimulates the innate immune response after activation by guanosine- and uridine-rich single-stranded RNA. Human but not murine TLR8 confers responsiveness to the antiviral compound R-848. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.

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Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

TLR8 (8)

Publications

No (7)

Yes (1)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His-S (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Myc-DDK (Flag), C-terminus (1)

Species

Human (6)

Rat (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (1)

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Human TLR8 Protein (Recombinant 6His, N-terminus) (aa27-827) - LS-G23167

(4.1) Rating

(2) Publication(s)

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

93.4 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human TLR8 Protein (Recombinant His-S) (aa844-1039) - LS-G14592

Source:

E. coli

Tag:

His-S

Molecular Weight:

29.0 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Human TLR8 Protein (Recombinant GST) (Full Length) - LS-G33721

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

146.2 kDa

Price:

2 µg/$439

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Human TLR8 Protein (Recombinant GST, N-terminus) (aa723-825) - LS-G62454

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TLR8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88926

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

119.6 kDa

Price:

20 µg/$215

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TLR8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107172

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

119.6 kDa

Price:

100 µg/$710

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Human TLR8 Protein (Recombinant Myc-DDK (Flag), C-terminus) (Full Length) - LS-G142151

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag), C-terminus

Molecular Weight:

119.6 kDa

Price:

20 µg/$1,107

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Rat TLR8 Protein (Recombinant His-T7) (aa519-812) - LS-G24588

Source:

E. coli

Tag:

His-T7

Molecular Weight:

38 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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