Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
TLR5 is a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.
Gene Name: | toll-like receptor 5 |
Family/Subfamily: | Toll-like Receptor , not assigned-Toll-like Receptor |
Synonyms: | TLR5, TIL3, Toll-like receptor 5, SLEB1 |
Target Sequences: | NM_003268 BAB43955.1 O60602 |
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