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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
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TLR5

toll-like receptor 5

TLR5 is a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.

Gene Name: toll-like receptor 5
Family/Subfamily: Toll-like Receptor , not assigned-Toll-like Receptor
Synonyms: TLR5, TIL3, Toll-like receptor 5, SLEB1
Target Sequences: NM_003268 BAB43955.1 O60602

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).