TLR4

toll-like receptor 4

Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+. Responses triggered by Ni2+ require non-conserved histidines and are, therefore, species-specific. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

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Products

ELISA Kits (28)

Type

Competitive EIA (2)

Development Kit (3)

Sandwich (20)

Sandwich CLIA (3)

Target

TLR4 (28)

Reactivity

Human (8)

Mouse (7)

Rat (7)

Bovine (2)

Guinea pig (1)

Pig (2)

Porcine (1)

Product Group

DevKit DuoPlus (3)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (3)

96-Well Strip Plate (21)

Antibody Pair and Standard (3)

Publications

No (25)

Yes (3)

Sample Type

Cell Culture Supernatants (8)

Cell Lysates (9)

Cell Supernatant (1)

Plasma (19)

Serum (19)

Tissue Homogenates (13)

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Human TLR4 (Sandwich ELISA) ELISA Kit - LS-F3675

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.41 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$635

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Pig TLR4 (Sandwich ELISA) ELISA Kit - LS-F15158

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human TLR4 (CLIA) ELISA Kit - LS-F29972

(4.0) Rating

(1) Publication(s)

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$863

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Rat TLR4 (Sandwich ELISA) ELISA Kit - LS-F22360

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.31 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Mouse TLR4 (Sandwich ELISA) ELISA Kit - LS-F21475

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

0.16 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Bovine TLR4 (Sandwich ELISA) ELISA Kit - LS-F15159

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Bovine

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Rat TLR4 (Sandwich ELISA) ELISA Kit - LS-F35042

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$587

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Mouse TLR4 (Sandwich ELISA) ELISA Kit - LS-F35043

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human TLR4 (Sandwich ELISA) ELISA Kit - LS-F4447

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

1 Plate/$764

Select

Mouse TLR4 (Sandwich ELISA) ELISA Kit - LS-F5705

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

1 Plate/$782

Select

Bovine TLR4 (Sandwich ELISA) ELISA Kit - LS-F5884

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Bovine

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$779

Select

Rat TLR4 (Sandwich ELISA) ELISA Kit - LS-F4846

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$715

Select

Mouse TLR4 (Sandwich ELISA) ELISA Kit - LS-F12777

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

Select

Mouse TLR4 (CLIA) ELISA Kit - LS-F26350

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

13.72 - 10000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

1 Plate/$871

Select

Rat TLR4 (Sandwich ELISA) ELISA Kit - LS-F12778

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

Select

Human TLR4 (Sandwich ELISA) ELISA Kit - LS-F27261

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.5 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

Select

Mouse TLR4 (Competitive EIA) ELISA Kit - LS-F28620

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.5 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

Select

Rat TLR4 (CLIA) ELISA Kit - LS-F37759

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

62.5 - 4000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Human TLR4 (Sandwich ELISA) ELISA Kit - LS-F35041

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human TLR4 (Sandwich ELISA) ELISA Kit - LS-F52729

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$968

Select

Porcine TLR4 (Sandwich ELISA) ELISA Kit - LS-F48650

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Guinea pig TLR4 (Sandwich ELISA) ELISA Kit - LS-F48649

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

DevKit DuoPlus Rat TLR4 ELISA Development Kit - LS-F71849

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

500 Wells/$1,254; 1000 Wells/$1,867

Select

DevKit DuoPlus Mouse TLR4 ELISA Development Kit - LS-F71712

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

500 Wells/$1,207; 1000 Wells/$1,787

Select

DevKit DuoPlus Human TLR4 ELISA Development Kit - LS-F71635

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Human

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

500 Wells/$1,182; 1000 Wells/$1,747

Viewing 1-25 of 28 product results

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