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TLR3

toll-like receptor 3

TLR3 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.

Gene Name: toll-like receptor 3
Family/Subfamily: Toll-like Receptor , not assigned-Toll-like Receptor
Synonyms: TLR3, CD283, Toll-like receptor 3, CD283 antigen, IIAE2
Target Sequences: NM_003265 NP_003256.1 O15455

Publications (6)

1
Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. Kong KF, Delroux K, Wang X, Qian F, Arjona A, Malawista SE, Fikrig E, Montgomery RR. Journal of virology. 2008 82:7613-23. [PubMed:18508883] [PMC:PMC2493309] Related Antibodies: LS-C40786.
2
KSHV inhibits stress granule formation by viral ORF57 blocking PKR activation. Sharma NR, Majerciak V, Kruhlak MJ, Zheng ZM. PLoS pathogens. 2017 13:e1006677. (WB; Human) [Full Text Article] [PubMed:29084250] Related Antibodies: LS-C19344.
3
A comparison of the impact of Shimen and C strains of classical swine fever virus on Toll-like receptor expression. Cao Z, Guo K, Zheng M, Ning P, Li H, Kang K, Lin Z, Zhang C, Liang W, Zhang Y. The Journal of general virology. 2015 96:1732-45. (WB; Human) [Full Text Article] [PubMed:25805409] Related Antibodies: LS-C545.
4
Tissue expression of Toll-like receptors 2, 3, 4 and 7 in swine in response to the Shimen strain of classical swine fever virus. Cao Z, Zheng M, Lv H, Guo K, Zhang Y. Molecular medicine reports. 2018 May;17:7122-7130. (Rabbit, Mouse) [Full Text Article] [PubMed:29568891] [PMC:PMC5928672] Related Antibodies: LS-C545.
5
Ontogeny of white matter, toll-like receptor expression, and motor skills in the neonatal ferret. Snyder JM, Wood TR, Corry K, Moralejo DH, Parikh P, Juul SE. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2018 November;70:25-33. [Full Text Article] [PubMed:29791868] [PMC:PMC6195435] Related Antibodies: LS-C545.
6
Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA. Sadik CD, Bachmann M, Pfeilschifter J, Mhl H. Nucleic acids research. 2009 37:5041-56. [PubMed:19541850] [PMC:PMC2731906] Related Antibodies: LS-C40786.
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TLR3 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$715
TLR3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
TLR3 ELISA Kit
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Development Kit
Antibody Pair and Standard
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
500 Wells/$1,254; 1000 Wells/$1,867
TLR3 ELISA Kit
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Sandwich
96-Well Microplate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
TLR3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
TLR3 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
TLR3 ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
TLR3 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Mouse
5.49 - 4000 pg/ml
Chemiluminescent
Plasma, Serum, Tissue Homogenates
1 Plate/$871
TLR3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TLR3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$582
TLR3 ELISA Kit
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Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$610
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).