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TJP3 / ZO3
tight junction protein 3
The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1.
| Gene Name: | tight junction protein 3 |
| Family/Subfamily: | Occludin , not assigned-Occludin |
| Synonyms: | TJP3, Tight junction protein 3, ZO-3, Zona occludens protein 3, Zonula occludens protein 3, Tight junction protein ZO-3, ZO3 |
| Target Sequences: | NM_014428 NP_055243.1 O95049 |
Publications (1)
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