TIP48 / RUVBL2

RuvB-like AAA ATPase 2

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

TIP48 / RUVBL2 (7)

Publications

No (7)

Tag

6His-SUMO, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human TIP48 / RUVBL2 Protein (Recombinant 6His-SUMO, N-terminus) (aa2-463) - LS-G64237

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human TIP48 / RUVBL2 Protein (Recombinant GST) (Full Length) - LS-G32362

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

76.67 kDa

Price:

10 µg/$479; 25 µg/$670

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Human TIP48 / RUVBL2 Protein (Recombinant GST, N-terminus) (aa353-462) - LS-G61662

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TIP48 / RUVBL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89043

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51 kDa

Price:

20 µg/$150

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Human TIP48 / RUVBL2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71161

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51 kDa

Price:

20 µg/$1,107

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TIP48 / RUVBL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100878

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51 kDa

Price:

100 µg/$494

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Human TIP48 / RUVBL2 Protein (Recombinant His) (aa210-384) - LS-G140854

Source:

E. coli

Sequence Length:

174 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

19.25 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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