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TIMP1

TIMP metallopeptidase inhibitor 1

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.

Gene Name: TIMP metallopeptidase inhibitor 1
Synonyms: TIMP1, CLGI, EPA, HCI, Metalloproteinase inhibitor 1, TIMP-1
Target Sequences: NM_003254 NP_003245.1 P01033

Publications (4)

1
Chronic binge alcohol administration accentuates expression of pro-fibrotic and inflammatory genes in the skeletal muscle of simian immunodeficiency virus-infected macaques. Dodd T, Simon L, LeCapitaine NJ, Zabaleta J, Mussell J, Berner P, Ford S, Dufour J, Bagby GJ, Nelson S, Molina PE. Alcoholism, clinical and experimental research. 2014 38:2697-706. (IHC; Human) [Full Text Article] [PubMed:25421506] [PMC:PMC4244658]
2
Osteoprotegerin Prevents Development of Abdominal Aortic Aneurysms. Bumdelger B, Kokubo H, Kamata R, Fujii M, Yoshimura K, Aoki H, Orita Y, Ishida T, Ohtaki M, Nagao M, Ishida M, Yoshizumi M. PloS one. 2016 11:e0147088. (IHC; Mouse) [Full Text Article] [PubMed:26783750] [PMC:PMC4718675]
3
Effect of anti-IL17 and/or Rho-kinase inhibitor treatments on vascular remodeling induced by chronic allergic pulmonary inflammation. Tabata M Dos Santos, Renato F Righetti, Bianca G Rezende, Elaine C Campos, Leandro do N Camargo, Beatriz M Saraiva-Romanholo, Silvia Fukuzaki, Carla M Prado, Edna A Leick, Milton A Martins, Iolanda F L C Tibério. Therapeutic advances in respiratory disease. 2020 December;14:1753466620962665. [Full Text Article] [PubMed:33357114] [PMC:PMC7768836] Related Antibodies: LS-C299465.
4
AKT-AMPKa-mTOR-dependent HIF-1a Activation is a New Therapeutic Target for Cancer Treatment: A Novel Approach to Repositioning the Antidiabetic Drug Sitagliptin for the Management of Hepatocellular Carcinoma. Eslam E Abd El-Fattah, Sameh Saber, Mahmoud E Youssef, Hanan Eissa, Eman El-Ahwany, Noha A Amin, Mohammed Alqarni, Gaber El-Saber Batiha, Ahmad J Obaidullah, Mohamed M Y Kaddah, Ahmed Gaafar Ahmed Gaafar, Ahmed A E Mourad, Gomaa Mostafa-Hedeab, Amir Mohamed Abdelhamid. Frontiers in pharmacology. 2022 February;12:720173. [Full Text Article] [PubMed:35095479] [PMC:PMC8790251]
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Products
ELISA Kits (63)
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Custom (4)
Development Kit (2)
Sandwich (49)
Sandwich CLIA (7)
TIMP1 (63)
Human (17)
Mouse (13)
Rat (11)
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Chicken (1)
Dog (2)
Guinea pig (2)
Horse (1)
Monkey (1)
Pig (4)
Porcine (1)
Rabbit (3)
Sheep (5)
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DevKit DuoPlus (1)
1000 Wells (1)
12 x 8-Well Microstrips (3)
96-Well Microplate (14)
96-Well Strip Plate (43)
Antibody Pair and Standard (1)
No (61)
Yes (2)
Cell Culture Supernatants (23)
Cell Lysates (11)
EDTA Plasma (1)
Heparin Plasma (1)
Plasma (53)
Saliva (2)
Serum (54)
Tissue Homogenates (25)
TIMP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TIMP1 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$744
TIMP1 ELISA Kit
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Sandwich
96-Well Microplate
Human
24.69 - 18000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
TIMP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Dog
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$748
TIMP1 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
TIMP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TIMP1 ELISA Kit
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Sandwich
96-Well Microplate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Saliva, Serum
1 Plate/$699
TIMP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$610
TIMP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
39.063 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TIMP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
4.69 - 300 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TIMP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$869
TIMP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$565
TIMP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
TIMP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$565
TIMP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$565
TIMP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TIMP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$826
TIMP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TIMP1 ELISA Kit
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Sandwich
Human
156 - 10000 pg/ml
Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Saliva, Serum
1 Plate/$699
TIMP1 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$528
TIMP1 ELISA Kit
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Sandwich
96-Well Microplate
Rabbit
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$565
TIMP1 ELISA Kit
Select
Sandwich
96-Well Microplate
Pig
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$565
TIMP1 ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Sheep
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,348; 1000 Wells/$2,021
TIMP1 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$528
TIMP1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$582
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).