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Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.
Gene Name: | TRAF-interacting protein with forkhead-associated domain |
Synonyms: | TIFA, TIFAA, T2BP, T6BP, TRAF2 binding protein, TRAF2-binding protein, TRAF6 binding protein |
Target Sequences: | NP_443096.1 Q96CG3 |
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