TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

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Products

Antibodies (74)

ELISA Kits (18)

Proteins (18)

Type

Cell-Based (1)

Custom (4)

Over-Expression Lysate (2)

Primary (74)

Recombinant (16)

Sandwich (13)

Target

TGFBR2 (110)

Reactivity

Human (72)

Mouse (55)

Rat (21)

Bat (1)

Bovine (1)

Chicken (3)

Chimpanzee (3)

Gibbon (3)

Guinea pig (1)

Horse (1)

Monkey (5)

Pig (4)

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Application

IHC (28)

IHC-P (7)

WB (57)

Flo (3)

ELISA (24)

ICC (5)

IF (12)

IP (1)

Peptide-ELISA (6)

SDS-PAGE (2)

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rabbit (64)

mouse (4)

goat (4)

sheep (2)

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IHCPlus (1)

PathPlus Cancer (2)

Isotype

IgG (46)

IgG1 (2)

IgG2a (2)

Clonality

monoclonal mc (4)

polyclonal pc (70)

Clone

OTI3B4 (2)

OTI4F3 (2)

Format

12 x 8-Well Microstrips (1)

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Epitope

aa209-590 (8)

aa13-40 (7)

aa548-575 (7)

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aa23-294 (4)

Extracellular Domain (3)

Internal (2)

pSer225 (2)

160-240 aa (1)

60-140 aa, Internal (1)

Glu246 (1)

aa100-150 (1)

aa191-240 (1)

aa25-159 (1)

aa27-85 (1)

aa330-346 (1)

aa475-525 (1)

aa517-567 (1)

aa73-122 (1)

aa77-148 (1)

aa91-140 (1)

aa96-128 (1)

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Publications

No (110)

Sample Type

Adherent Cell Cultures (1)

Cell Culture Supernatants (3)

Cell Lysates (3)

Cell Supernatant (1)

Plasma (11)

Serum (11)

Tissue Homogenates (7)

Tag

10His, N-terminus + Myc, C-terminus (1)

6His, C-terminus (2)

Fc (1)

Fc, C-terminus (5)

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His (1)

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Human IgG Fc, C-terminus (1)

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Species

Human (8)

Mouse (6)

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Source

293T Cells (1)

Baculovirus (2)

E. coli (1)

HEK 293 Cells (3)

Human (1)

Human Cells (4)

Mammalian Cells (3)

Wheat Germ Extract (3)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (10)

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PathPlus™ TGFBR2 Antibody (aa13-40) LS-B12077

Cancer

(5.0) Rating

Antibody:

TGFBR2 Rabbit anti-Human Polyclonal (aa13-40) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

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TGFBR2 Antibody (APC) LS-C184147

Antibody:

TGFBR2 Goat anti-Mouse Polyclonal (APC) Antibody

Reactivity:

Mouse

Applications:

Flo

Format:

APC Conjugated

Price:

100 Tests/$896

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PathPlus™ TGFBR2 Antibody (aa517-567) LS-B12184

Cancer

(5.0) Rating

Antibody:

TGFBR2 Rabbit anti-Human Polyclonal (aa517-567) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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TGFBR2 Antibody (Internal) LS-C368750

Antibody:

TGFBR2 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Rabbit, Mouse, Rat, Pig, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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Mouse TGFBR2 Protein (Recombinant 6His, C-terminus) (Ile24-Asp159) - LS-G40156

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

16.2kD

Price:

10 µg/$266; 50 µg/$343; 500 µg/$1,869; 1 mg/$2,991

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Mouse TGFBR2 Protein (Recombinant Fc, C-terminus) (Ile24-Asp159) - LS-G40155

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

42.3kD

Price:

10 µg/$266; 50 µg/$343; 500 µg/$1,377; 1 mg/$1,765

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TGFBR2 Antibody (Extracellular Domain, PerCP) LS-C182963

Antibody:

TGFBR2 Goat anti-Mouse Polyclonal (Extracellular Domain) (PerCP) Antibody

Reactivity:

Mouse

Applications:

Flo

Format:

PerCP Conjugated

Price:

100 Tests/$859

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Rat TGFBR2 Protein (Recombinant 10His, N-terminus + Myc, C-terminus) (aa24-166) - LS-G55970

Source:

Baculovirus

Tag:

10His, N-terminus + Myc, C-terminus

Price:

100 µg/$810; 20 µg/$387; 1 mg/$1,678

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TGFBR2 Antibody LS-C499922

Antibody:

TGFBR2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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TGFBR2 Antibody (aa25-159, HRP) LS-C499926

Antibody:

TGFBR2 Rabbit anti-Human Polyclonal (aa25-159) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP

• Unconjugated
• HRP

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TGFBR2 Antibody (phospho-Ser225) LS-C412249

Antibody:

TGFBR2 Rabbit anti-Human Polyclonal (pSer225) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$431

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TGFBR2 Antibody (aa13-40) LS-C325701

Antibody:

TGFBR2 Rabbit anti-Human Polyclonal (aa13-40) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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TGFBR2 Antibody (aa13-40, FITC) LS-C271396

Antibody:

TGFBR2 Rabbit anti-Mouse Polyclonal (aa13-40) (FITC) Antibody

Reactivity:

Mouse

Applications:

ELISA, ICC, IF, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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TGFBR2 Antibody (aa13-40, PE) LS-C271397

Antibody:

TGFBR2 Rabbit anti-Mouse Polyclonal (aa13-40) (PE) Antibody

Reactivity:

Mouse

Applications:

ELISA, ICC, IF, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

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TGFBR2 Antibody (aa13-40, APC) LS-C271394

Antibody:

TGFBR2 Rabbit anti-Mouse Polyclonal (aa13-40) (APC) Antibody

Reactivity:

Mouse

Applications:

ELISA, ICC, IF, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

• Unconjugated
• FITC
• PE
• APC

• Unconjugated
• FITC
• PE
• More...
  • APC

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TGFBR2 Antibody LS-C747135

Antibody:

TGFBR2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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Mouse TGFBR2 (Sandwich ELISA) ELISA Kit - LS-F8659

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$748

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TGFBR2 Antibody (aa23-294, clone OTI3B4) LS-C794199

Antibody:

TGFBR2 Mouse anti-Human Monoclonal (aa23-294) (OTI3B4) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

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TGFBR2 Antibody (Glu246) LS-C176560

Antibody:

TGFBR2 Rabbit anti-Human Polyclonal (Glu246) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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TGFBR2 Antibody (aa548-575) LS-C325698

Antibody:

TGFBR2 Rabbit anti-Mouse Polyclonal (aa548-575) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

TGFBR2 Antibody (aa475-525) LS-C291051

Antibody:

TGFBR2 Rabbit anti-Human Polyclonal (aa475-525) Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

Select

Human TGFBR2 Protein (Recombinant His,C-terminus) - LS-G141195

Source:

Baculovirus

Tag:

His,C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human TGFBR2 consists of 154 amino acids and predicts a molecular mass of 17.7 kDa.

Price:

100 µg/$441; 1 mg/$2,003

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Mouse TGFBR2 Protein (Recombinant 6His, C-terminus) (Ile24-Asp159) - LS-G138857

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

16.2 kDa

Price:

10 µg/$266; 50 µg/$339

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TGFBR2 Antibody (60-140 aa, Internal) LS-C386403

Antibody:

TGFBR2 Rabbit anti-Human Polyclonal (60-140 aa, Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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TGFBR2 Antibody (aa91-140) LS-C118587

Antibody:

TGFBR2 Rabbit anti-Human Polyclonal (aa91-140) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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