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TFIIB is the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II.
Gene Name: | general transcription factor IIB |
Synonyms: | GTF2B, S300-II, TFIIB, TF2B |
Target Sequences: | NM_001514 NP_001505.1 Q00403 |
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