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TFF3 / Trefoil Factor 3

trefoil factor 3 (intestinal)

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. TFF3 is expressed in goblet cells of the intestines and colon. The TFF3 gene consists of 3 exons, with exon 2 encoding the trefoil domain. The TFF1, TFF2, and TFF3 genes are located within a 55 kb region, suggesting they evolved from a common ancestor by duplication.

Gene Name: trefoil factor 3 (intestinal)
Synonyms: TFF3, HP1.B, Intestinal trefoil factor, HITF, ITF, TFI, p1B, Polypeptide P1.B, Trefoil factor 3, Trefoil factor 3 (intestinal)
Target Sequences: NM_003226

Publications (2)

1
Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating Tff3 Expression. Zhu Y, Zhao S, Deng Y, Gordillo R, Ghaben AL, Shao M, Zhang F, Xu P, Li Y, Cao H, Zagnitko O, Scott DA, Gupta RK, Xing C, Zhang BB, Lin HV, Scherer PE. Diabetes. 2017 November;66:2789-2799. [Full Text Article] [PubMed:28877911] [PMC:PMC5652600]
2
A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity. Lei Chen, Natalie H Toke, Shirley Luo, Roshan P Vasoya, Robert L Fullem, Aditya Parthasarathy, Ansu O Perekatt, Michael P Verzi. Nature genetics. 2019 May;51:777-785. [Full Text Article] [PubMed:30988513] [PMC:PMC6650150] Related Antibodies: LS-C662731.

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Products
ELISA Kits (35)
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TFF3 / Trefoil Factor 3 (35)
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Mouse (7)
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Serum (28)
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TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich
96-Well Microplate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Saliva, Serum, Urine
1 Plate/$699
TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$750
TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
46.88 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$812
TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich
96-Well Microplate
Human
2.048 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$635
TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$610
TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates, Urine
1 Plate/$822
TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$671
TFF3 / Trefoil Factor 3 ELISA Kit
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Development Kit
Antibody Pair and Standard
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
500 Wells/$1,305; 1000 Wells/$1,952
TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich
Mouse
31.2 - 2000 pg/ml
Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Serum
1 Plate/$699
TFF3 / Trefoil Factor 3 ELISA Kit
Select
Sandwich
Rat
31.2 - 2000 pg/ml
Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Serum
1 Plate/$699
TFF3 / Trefoil Factor 3 ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,005; 1000 Wells/$1,451
TFF3 / Trefoil Factor 3 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
0.16 - 120 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$851
TFF3 / Trefoil Factor 3 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).