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TFEB

transcription factor EB

Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.

Gene Name: transcription factor EB
Family/Subfamily: Transcription factor
Synonyms: TFEB, ALPHATFEB, BHLHE35, T-cell transcription factor EB, TCFEB, Transcription factor EB
Target Sequences: NM_007162 NP_009093.1 P19484

Publications (2)

1
RIP3 impedes transcription factor EB to suppress autophagic degradation in septic acute kidney injury. Ruizhao Li , Xingchen Zhao , Shu Zhang , Wei Dong, Li Zhang, Yuanhan Chen, Zhilian Li, Huan Yang, Ying Huang, Zhiyong Xie, Weidong Wang, Chunling Li, Zhiming Ye, Zheng Dong, Xinling Liang. Cell death & disease. 2021 June;12:593. [Full Text Article] [PubMed:34103472] [PMC:PMC8187512]
2
RanBP9 overexpression reduces dendritic arbor and spine density. Wang H, Lewsadder M, Dorn E, Xu S, Lakshmana MK. Neuroscience. 2014 Apr;265:253-62. [Full Text Article] [PubMed:24486966] [PMC:PMC3972333] Related Antibodies: LS-C118813.

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Antibodies (50)
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TFEB (50)
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rabbit (45)
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polyclonal pc (45)
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aa271-300 (7)
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aa10-59 (1)
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aa289-301 (1)
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TFEB Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TFEB Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
TFEB Antibody - Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using TFEB Antibody. The picture on the right is blocked with the synthesized peptide.
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TFEB Rabbit anti-Human Polyclonal (aa10-59) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
TFEB Antibody - Anti-TFEB antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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TFEB Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
TFEB Antibody - Anti-TFEB antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
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TFEB Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$460
TFEB Antibody - Immunofluorescence of monoclonal antibody to TFEB on HeLa cell. [antibody concentration 20 ug/ml]
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TFEB Mouse anti-Human Monoclonal (S1) Antibody
Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$423
TFEB Antibody - Western blot of TFEB antibody
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TFEB Rabbit anti-Human Polyclonal (10-90 aa, N-terminal) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TFEB Antibody - Western blot analysis of TFEB expression in A549 (A); NIH3T3 (B); H9C2 (C) whole cell lysates.
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TFEB Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
WB
Unconjugated
100 µl/$299
TFEB Antibody
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TFEB Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$445
TFEB Antibody - Detection of Human TFEB by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-TFEB used at a dilution of 1:1000 (1 Detection: DAB.
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TFEB Rabbit anti-Human Polyclonal (aa426-476) Antibody
Mouse, Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
TFEB Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TFEB Rabbit anti-Human Polyclonal (aa15-64) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
TFEB Antibody - A: Marker, B: HepG2 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TFEB Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$397
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TFEB Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$341
TFEB Antibody - Immunohistochemistry of paraffin-embedded human tonsil using antibody at 1:100 dilution.
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TFEB Rabbit anti-Human Polyclonal (aa1-220) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
TFEB Antibody - Immunohistochemistry of paraffin-embedded human placenta tissue using TFEB Antibody at dilution of 1:100
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TFEB Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
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TFEB Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
TFEB Antibody - Immunofluorescence analysis of HeLa cells using TFEB Polyclonal Antibody at dilution of 1:100.Blue: DAPI for nuclear staining.
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TFEB Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TFEB Antibody - Immunohistochemistry of paraffin-embedded human tonsil using antibody at 1:100 dilution.
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TFEB Rabbit anti-Human Polyclonal (aa1-220) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
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TFEB Rabbit anti-Human Polyclonal (aa6-51) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$314; 100 µl/$391
TFEB Antibody - Western blot of TFEB expression in Mouse lung tissue lysates,The lane on the left is treated with the antigen-specific peptide.
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TFEB Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
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TFEB Rabbit anti-Human Polyclonal (aa271-300) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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TFEB Rabbit anti-Human Polyclonal (aa271-300) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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TFEB Rabbit anti-Human Polyclonal (aa271-300) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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TFEB Rabbit anti-Human Polyclonal (aa271-300) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
TFEB Antibody - Western blot analysis of immunized recombinant protein, using anti-TFEB monoclonal antibody.
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TFEB Mouse anti-Human Monoclonal (319C2a) Antibody
Human
DB, WB
Unconjugated
100 µg/$486
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TFEB Rabbit anti-Human Polyclonal (aa325-375) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).