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Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Gene Name: | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) |
Synonyms: | TFAP2C, AP2 Gamma, AP-2 gamma, ERF-1, ERF1, HAP-2g, Transcription factor ERF-1, TFAP2G, AP2-GAMMA, Estrogen receptor factor 1 |
Target Sequences: | NM_003222 NP_003213.1 Q92754 |
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