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Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
Gene Name: | transcription factor AP-2 beta (activating enhancer binding protein 2 beta) |
Synonyms: | TFAP2B, AP-2 beta, AP-2B, AP2-BETA, CHAR, Transcription factor AP-2-beta, AP2 Beta, AP2-B |
Target Sequences: | NM_003221 NP_003212.2 Q92481 |
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