TET3

Tet Methylcytosine Dioxygenase 3

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.

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Products

Antibodies (29)

Type

Primary (29)

Target

TET3 (29)

Reactivity

Human (29)

Mouse (4)

Rat (2)

Application

IHC (11)

IHC-P (8)

WB (24)

ELISA (7)

ICC (1)

IF (3)

Peptide-ELISA (1)

Host

rabbit (11)

mouse (18)

Product Group

IHCPlus (2)

Isotype

IgG (9)

IgG1 (14)

IgG2a (2)

IgG2b (2)

Clonality

monoclonal mc (18)

polyclonal pc (11)

Clone

1.10E+12 (1)

11E11 (1)

OTI10G4 (2)

OTI11H8 (2)

OTI15H3 (2)

OTI2F10 (2)

OTI3B3 (2)

OTI3G10 (2)

OTI4B7 (2)

OTI5A4 (2)

Format

Biotin Conjugated (1)

Carrier-free (9)

FITC Conjugated (1)

HRP Conjugated (1)

Unconjugated (26)

Epitope

aa241-568 (18)

aa1-160 (2)

Publications

No (29)

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IHC-plus™ TET3 Antibody (aa241-568, clone 11E11) LS-B13292

(4.0) Rating

Antibody:

TET3 Mouse anti-Human Monoclonal (aa241-568) (11E11) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$375

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IHC-plus™ TET3 Antibody LS-B8858

(4.0) Rating

Antibody:

TET3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$375

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TET3 Antibody (aa241-568, clone OTI3G10) LS-C338921

Antibody:

TET3 Mouse anti-Human Monoclonal (aa241-568) (OTI3G10) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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TET3 Antibody (aa241-568, clone OTI3G10, Carrier-free) LS-C790062

Antibody:

TET3 Mouse anti-Human Monoclonal (aa241-568) (Carrier-free) (OTI3G10) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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TET3 Antibody LS-C409185

Antibody:

TET3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389

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TET3 Antibody (aa241-568, clone 1.10E+12, Carrier-free) LS-C790092

Antibody:

TET3 Mouse anti-Human Monoclonal (aa241-568) (Carrier-free) (1.10E+12) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

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TET3 Antibody (aa241-568, clone OTI4B7) LS-C338952

Antibody:

TET3 Mouse anti-Human Monoclonal (aa241-568) (OTI4B7) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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TET3 Antibody (aa241-568, clone OTI4B7, Carrier-free) LS-C790095

Antibody:

TET3 Mouse anti-Human Monoclonal (aa241-568) (Carrier-free) (OTI4B7) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

TET3 Antibody LS-C820550

Antibody:

TET3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF

Format:

Unconjugated

Price:

100 µl/$302

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TET3 Antibody LS-C370403

Antibody:

TET3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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TET3 Antibody (HRP) LS-C370406

Antibody:

TET3 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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TET3 Antibody (Biotin) LS-C370407

Antibody:

TET3 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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TET3 Antibody (FITC) LS-C370404

Antibody:

TET3 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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TET3 Antibody (aa1-160) LS-C744618

Antibody:

TET3 Rabbit anti-Human Polyclonal (aa1-160) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

25 µl/$304

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TET3 Antibody (aa1-160) LS-C744619

Antibody:

TET3 Rabbit anti-Human Polyclonal (aa1-160) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$567

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TET3 Antibody LS-C803598

Antibody:

TET3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$282; 200 µl/$350

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TET3 Antibody (aa241-568, clone OTI3B3) LS-C338935

Antibody:

TET3 Mouse anti-Human Monoclonal (aa241-568) (OTI3B3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

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TET3 Antibody (aa241-568, clone OTI3B3, Carrier-free) LS-C790074

Antibody:

TET3 Mouse anti-Human Monoclonal (aa241-568) (Carrier-free) (OTI3B3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

TET3 Antibody (aa241-568, clone OTI11H8) LS-C338936

Antibody:

TET3 Mouse anti-Human Monoclonal (aa241-568) (OTI11H8) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

TET3 Antibody (aa241-568, clone OTI11H8, Carrier-free) LS-C790077

Antibody:

TET3 Mouse anti-Human Monoclonal (aa241-568) (Carrier-free) (OTI11H8) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

TET3 Antibody (aa241-568, clone OTI5A4) LS-C338917

Antibody:

TET3 Mouse anti-Human Monoclonal (aa241-568) (OTI5A4) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

TET3 Antibody (aa241-568, clone OTI5A4, Carrier-free) LS-C790061

Antibody:

TET3 Mouse anti-Human Monoclonal (aa241-568) (Carrier-free) (OTI5A4) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

TET3 Antibody (aa241-568, clone OTI2F10) LS-C338948

Antibody:

TET3 Mouse anti-Human Monoclonal (aa241-568) (OTI2F10) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

TET3 Antibody (aa241-568, clone OTI10G4) LS-C338950

Antibody:

TET3 Mouse anti-Human Monoclonal (aa241-568) (OTI10G4) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

TET3 Antibody (aa241-568, clone OTI15H3) LS-C338951

Antibody:

TET3 Mouse anti-Human Monoclonal (aa241-568) (OTI15H3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

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