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TEAD3
TEA domain family member 3
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
| Gene Name: | TEA domain family member 3 |
| Synonyms: | TEAD3, DTEF-1, ETFR-1, TEA domain family member 3, TEA domain family member 5, TEAD-3, TEAD5, TEF-5, TEF5 |
| Target Sequences: | NM_003214 NP_003205.2 Q99594 |
Publications (4)
1
Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis. Feiyang Ma , Pei-Suen Tsou , Mehrnaz Gharaee-Kermani, Olesya Plazyo, Xianying Xing, Joseph Kirma, Rachael Wasikowski, Grace A Hile, Paul W Harms, Yanyun Jiang, Enze Xing, Mio Nakamura, Danielle Ochocki, William D Brodie, Shiv Pillai, Emanual Maverakis, Matteo Pellegrini, Robert L Modlin, John Varga, Lam C Tsoi, Robert Lafyatis, J Michelle Kahlenberg, Allison C Billi, Dinesh Khanna, Johann E Gudjonsson. Nature communications. 2024 January;15:210. [Full Text Article]
[PubMed:38172207]
[PMC:PMC10764940]
Related Antibodies: LS-C668058.
2
YAP promotes ovarian cancer cell tumorigenesis and is indicative of a poor prognosis for ovarian cancer patients. Xia Y, Chang T, Wang Y, Liu Y, Li W, Li M, Fan HY. PloS one. 2014 9:e91770. [Full Text Article]
[PubMed:24622501]
[PMC:PMC3951505]
Related Antibodies: LS-C30406.
3
YAP/TEAD co-activator regulated pluripotency and chemoresistance in ovarian cancer initiated cells. Xia Y, Zhang YL, Yu C, Chang T, Fan HY. PloS one. 9:e109575. [Full Text Article]
[PubMed:25369529]
[PMC:PMC4219672]
Related Antibodies: LS-C30406.
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(36)
Yes
(3)
TEAD3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$424
TEAD3 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
TEAD3 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Pig, Horse, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
TEAD3 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Pig, Horse, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
TEAD3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
TEAD3 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321
TEAD3 Rabbit anti-Human Polyclonal (aa281-330) Antibody
Human
WB
Unconjugated
100 µl/$424
TEAD3 Rabbit anti-Human Polyclonal (aa82-110) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
400 µl/$393
![TEAD3 Antibody - Immunofluorescence of monoclonal antibody to TEAD3 on HeLa cell . [antibody concentration 10 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/tead3-antibody-clone-1c4-ls-c198322/146762_4987519.jpg)
TEAD3 Mouse anti-Human Monoclonal (1C4) Antibody
Human
ELISA, IF
Unconjugated
100 µg/$423
TEAD3 Rabbit anti-Human Polyclonal (aa143-192) Antibody
Human
WB
Unconjugated
100 µl/$424
TEAD3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
TEAD3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
TEAD3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TEAD3 Rabbit anti-Human Polyclonal (aa82-110) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
TEAD3 Rabbit anti-Human Polyclonal (aa82-110) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
TEAD3 Rabbit anti-Human Polyclonal (aa82-110) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
TEAD3 Rabbit anti-Human Polyclonal (aa82-110) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
TEAD3 Rabbit anti-Human Polyclonal (aa82-110) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
TEAD3 Rabbit anti-Human Polyclonal (aa82-110) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
TEAD3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
TEAD3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
TEAD3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
TEAD3 Rabbit anti-Human Polyclonal (180-260 aa, Internal) Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TEAD3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
TEAD3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
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