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TDRKH
tudor and KH domain containing
Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.
| Gene Name: | tudor and KH domain containing |
| Synonyms: | TDRKH, TDRD2, Tudor domain containing 2, Tudor and KH domain containing, Putative RNA binding protein |
| Target Sequences: | NM_006862 NP_006853.2 Q9Y2W6 |
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