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TDO2

tryptophan 2,3-dioxygenase

TDO2 is a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.

Gene Name: tryptophan 2,3-dioxygenase
Synonyms: TDO2, TDO, TO, TRPO, Tryptophan pyrrolase, Tryptophan oxygenase, Tryptophan 2,3-dioxygenase, Tryptophanase, Tryptamin 2,3-dioxygenase
Target Sequences: NM_005651 NP_005642.1 P48775

Publications (4)

1
Prognostic Significance of Tryptophan Catabolism in Adult T-cell Leukemia/Lymphoma. Masaki A, Ishida T, Maeda Y, Suzuki S, Ito A, Takino H, Ogura H, Totani H, Yoshida T, Kinoshita S, Narita T, Ri M, Kusumoto S, Inagaki A, Komatsu H, Niimi A, Ueda R, Utsunomiya A, Inagaki H, Iida S. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 21:2830-9. (IHC, IF; Human) [Full Text Article] [PubMed:25788494] Related Antibodies: LS-C174023.
2
Restoration of energy homeostasis by SIRT6 extends healthy lifespan. A Roichman , S Elhanati , M A Aon, I Abramovich, A Di Francesco, Y Shahar, M Y Avivi, M Shurgi, A Rubinstein, Y Wiesner, A Shuchami, Z Petrover, I Lebenthal-Loinger, O Yaron, A Lyashkov, C Ubaida-Mohien, Y Kanfi, B Lerrer, P J Fernández-Marcos, M Serrano, E Gottlieb, R de Cabo, H Y Cohen. Nature communications. 2021 May;12:3208. [Full Text Article] [PubMed:34050173] [PMC:PMC8163764] Related Antibodies: LS-C748245.
3
Expression of Tryptophan 2,3-Dioxygenase in Metastatic Uveal Melanoma. Mizue Terai, Eric Londin, Ankit Rochani, Emma Link, Bao Lam, Gagan Kaushal, Alok Bhushan, Marlana Orloff, Takami Sato. Cancers. 2020 Feb;12:405. [Full Text Article] [PubMed:32050636] [PMC:PMC7072257] Related Antibodies: LS-B5791.
4
The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat. Nagy-Grócz G, Laborc KF, Veres G, Bajtai A, Bohár Z, Zádori D, Fejes-Szabó A, Spekker E, Vécsei L, Párdutz Á. Frontiers in neurology. 2017 8:278. (WB; Rat) [Full Text Article] [PubMed:28659861] [PMC:PMC5469907] Related Antibodies: LS-C111058.
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Products
Proteins (11)
Over-Expression Lysate (2)
Recombinant (9)
TDO2 (11)
No (11)
6His-SUMO, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (4)
His-SUMO (1)
Myc-DDK (Flag) (3)
Human (7)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (4)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Yeast (2)
Purified (4)
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Yeast
His
49.7 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
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293T Cells
Myc-DDK (Flag)
47.7 kDa
20 µg/$150
TDO2 Protein
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Yeast
His
49.9 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
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E. coli
His
~47.9kDa
50 µg/$484
TDO2 Protein
Select
E. coli
His
10 µg/$361; 50 µg/$739
TDO2 Protein - 12.5% SDS-PAGE of human TDO2 stained with Coomassie Blue
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Wheat Germ Extract
GST
74.3 kDa
10 µg/$479; 25 µg/$670
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E. coli
His-SUMO
63.8 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
TDO2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
2 µg/$439
TDO2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
TDO2 Protein - Purified recombinant protein TDO2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
47.7 kDa
20 µg/$1,107
TDO2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
47.7 kDa
100 µg/$494
Viewing 1-11 of 11 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).