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TDO2
tryptophan 2,3-dioxygenase
TDO2 is a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.
| Gene Name: | tryptophan 2,3-dioxygenase |
| Synonyms: | TDO2, TDO, TO, TRPO, Tryptophan pyrrolase, Tryptophan oxygenase, Tryptophan 2,3-dioxygenase, Tryptophanase, Tryptamin 2,3-dioxygenase |
| Target Sequences: | NM_005651 NP_005642.1 P48775 |
Publications (4)
1
Prognostic Significance of Tryptophan Catabolism in Adult T-cell Leukemia/Lymphoma. Masaki A, Ishida T, Maeda Y, Suzuki S, Ito A, Takino H, Ogura H, Totani H, Yoshida T, Kinoshita S, Narita T, Ri M, Kusumoto S, Inagaki A, Komatsu H, Niimi A, Ueda R, Utsunomiya A, Inagaki H, Iida S. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 21:2830-9. (IHC, IF; Human)
[Full Text Article]
[PubMed:25788494]
Related Antibodies: LS-C174023.
2
Restoration of energy homeostasis by SIRT6 extends healthy lifespan. A Roichman , S Elhanati , M A Aon, I Abramovich, A Di Francesco, Y Shahar, M Y Avivi, M Shurgi, A Rubinstein, Y Wiesner, A Shuchami, Z Petrover, I Lebenthal-Loinger, O Yaron, A Lyashkov, C Ubaida-Mohien, Y Kanfi, B Lerrer, P J Fernández-Marcos, M Serrano, E Gottlieb, R de Cabo, H Y Cohen. Nature communications. 2021 May;12:3208. [Full Text Article]
[PubMed:34050173]
[PMC:PMC8163764]
Related Antibodies: LS-C748245.
3
Expression of Tryptophan 2,3-Dioxygenase in Metastatic Uveal Melanoma. Mizue Terai, Eric Londin, Ankit Rochani, Emma Link, Bao Lam, Gagan Kaushal, Alok Bhushan, Marlana Orloff, Takami Sato. Cancers. 2020 Feb;12:405. [Full Text Article]
[PubMed:32050636]
[PMC:PMC7072257]
Related Antibodies: LS-B5791.
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Antibodies
(27)
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(27)
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TDO2
(27)
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(27)
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(4)
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(3)
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(2)
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(2)
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(5)
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(5)
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(2)
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(5)
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(2)
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(2)
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(2)
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(9)
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(7)
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(25)
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(8)
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(18)
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(9)
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(2)
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(14)
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(6)
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(9)
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(18)
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(1)
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(3)
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(4)
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(2)
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(1)
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(17)
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(7)
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(4)
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(3)
Publications
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(23)
Yes
(4)
TDO2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$375
TDO2 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Dog, Human, Monkey, Gibbon
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
TDO2 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Dog, Human, Monkey, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
TDO2 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Dog, Human, Monkey, Gibbon
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
TDO2 Mouse anti-Human Monoclonal (OTI2A4) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
TDO2 Mouse anti-Human Monoclonal (Carrier-free) (OTI2A4) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TDO2 Mouse anti-Human Monoclonal (4G2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$375
TDO2 Rabbit anti-Human Polyclonal (aa71-120) Antibody
Human
WB
Unconjugated
100 µl/$424
TDO2 Rabbit anti-Human Polyclonal (aa71-120) (Biotin) Antibody
Xenopus, Rat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Human, Monkey, Chimpanzee, Gibbon
WB
Biotin Conjugated
100 µl/$469
TDO2 Mouse anti-Human Monoclonal (OTI1D1) Antibody
Human
Flo, WB
Unconjugated
100 µl/$434
TDO2 Mouse anti-Human Monoclonal (Carrier-free) (OTI1D1) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
TDO2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
TDO2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
TDO2 Mouse anti-Human Monoclonal (OTI1B1) Antibody
Human
WB
Unconjugated
100 µl/$434
TDO2 Mouse anti-Human Monoclonal (Carrier-free) (OTI1B1) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
TDO2 Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
WB
Unconjugated
400 µl/$393
TDO2 Mouse anti-Human Monoclonal (Carrier-free) (4G2) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TDO2 Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
TDO2 Rabbit anti-Human Polyclonal (aa1-30) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
TDO2 Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
TDO2 Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
TDO2 Rabbit anti-Human Polyclonal (aa1-30) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
TDO2 Rabbit anti-Human Polyclonal (aa1-30) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
TDO2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
TDO2 Mouse anti-Human Monoclonal (1C8) Antibody
Human
ELISA
Unconjugated
100 µg/$335
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product results
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