TDG / Thymine DNA Glycosylase

thymine-DNA glycosylase

DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

TDG / Thymine DNA Glycosylase (4)

Publications

No (4)

Tag

GST (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human TDG / Thymine DNA Glycosylase Protein (Recombinant His) - LS-G1923

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human TDG / Thymine DNA Glycosylase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81623

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.9 kDa

Price:

20 µg/$150

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Human TDG / Thymine DNA Glycosylase Protein (Recombinant GST) (Full Length) - LS-G30661

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

72.4 kDa

Price:

10 µg/$479; 25 µg/$670

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TDG / Thymine DNA Glycosylase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99993

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.9 kDa

Price:

100 µg/$494

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