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TCEB1 / Elongin C

transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)

SIII / TCEB1 is the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified.

Gene Name: transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
Synonyms: TCEB1, Elongin 15 kDa subunit, EloC, SIII, SIII p15, Elongin-C
Target Sequences: NM_005648 NP_005639.1 Q15369

Publications (3)

1
COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase. Maine GN, Mao X, Komarck CM, Burstein E. The EMBO journal. 2007 26:436-47. [PubMed:17183367] [PMC:PMC1783443]
2
GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA. Mao X, Gluck N, Li D, Maine GN, Li H, Zaidi IW, Repaka A, Mayo MW, Burstein E. Genes & development. 2009 23:849-61. [PubMed:19339690] [PMC:PMC2666342]
3
COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. Mao X, Gluck N, Chen B, Starokadomskyy P, Li H, Maine GN, Burstein E. The Journal of biological chemistry. 2011 286:32355-65. [PubMed:21778237] [PMC:PMC3173175]

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TCEB1 / Elongin C Protein
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100 µg/$361; 500 µg/$739; 20 µg/$261
TCEB1 / Elongin C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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12.3 kDa
20 µg/$150
TCEB1 / Elongin C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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12.3 kDa
100 µg/$494
TCEB1 / Elongin C Protein - Recombinant Elongin C (ELOC) by SDS-PAGE
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16.2kDa
10 µg/$290; 50 µg/$500; 200 µg/$997; 100 µg/$797; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329
TCEB1 / Elongin C Protein
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E. coli
GST
39.9 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
TCEB1 / Elongin C Protein - 12.5% SDS-PAGE of human TCEB1 stained with Coomassie Blue
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GST
38.06 kDa
10 µg/$479; 25 µg/$670
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).