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Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene.
Gene Name: | tubulin folding cofactor E |
Synonyms: | TBCE, Kenny-Caffey syndrome, KCS, Tubulin folding cofactor E, Tubulin-specific chaperone E, HRD, KCS1, Pac2, Tubulin-folding cofactor E |
Target Sequences: | NM_003193 NP_003184.1 Q15813 |
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