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TBCK / TBCKL encodes a protein that contains a protein kinase domain, a Rhodanase-like domain and the Tre-2/Bub2/Cdc16 (TBC) domain. The encoded protein is thought to play a role in actin organization, cell growth and cell proliferation by regulating the mammalian target of the rapamycin (mTOR) signaling pathway. This protein may also be involved in the transcriptional regulation of the components of the mTOR complex. Alternative splicing results in multiple transcript variants.
Gene Name: | TBC1 domain containing kinase |
Family/Subfamily: | Protein Kinase , TBCK |
Synonyms: | TBCK, TBCKL, TBC1 domain containing kinase, HSPC302 |
Target Sequences: | NM_033115 NP_149106.2 Q8TEA7 |
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