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TBCA is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Name: | tubulin folding cofactor A |
Synonyms: | TBCA, Chaperonin cofactor A, CFA, Co-chaperonin 'cofactor a', Tubulin-specific chaperone A, Tubulin-folding cofactor A, TCP1-chaperonin cofactor A, Tubulin folding cofactor A |
Target Sequences: | NM_004607 NP_004598.1 O75347 |
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