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TAS2R4 / T2R4
taste receptor, type 2, member 4
Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.
| Gene Name: | taste receptor, type 2, member 4 |
| Family/Subfamily: | GPCR , Taste |
| Synonyms: | TAS2R4, Candidate taste receptor T2R4, T2R4, Taste receptor type 2 member 4 |
| Target Sequences: | NM_016944 NP_058640.1 Q9NYW5 |
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