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Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic activity is enhanced by binding to heme.
Gene Name: | neudesin neurotrophic factor |
Synonyms: | NENF, CIR2, Neudesin, Neudesin neurotrophic factor, SCIRP10, SCIRP10-related protein, SPUF protein, SPUF |
Target Sequences: | NM_013349 NP_037481.1 Q9UMX5 |
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