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CTSB / Cathepsin B

cathepsin B

Cathepsin B is a lysosomal cysteine proteinase synthesized as a zymogen of 39-47 kilodaltons (kD), which is subsequently converted into an active single- chain form of 33 kD (CB33) and, by additional processing, into the active 2-chain form containing a heavy chain of 27-29 kD (CB(27-29)) and a light chain of 4-6 kD. Cathepsin B is usually found in perinuclear lysosomes of epithelial cells of normal organs and non-malignant tumors, but is associated with the plasma membranes of many solid organ malignant tumors. Cathepsin B, a marker of the dedifferentiated chondrocyte phenotype, has been shown to contribute to cartilage destruction in osteoarthritis and pathological proteolysis in rheumatoid arthritis and cancer. Increased or altered CB expression has been documented in a variety of tumor cells. It has also been suggested that a cat B-mitochondrial apoptotic pathway plays a pivotal role in TNF-alpha-induced hepatocyte apoptosis and liver injury.

Gene Name: cathepsin B
Family/Subfamily: Protease , Cysteine C1
Synonyms: CTSB, Cathepsin B1, Cathepsin B, Cathepsins B, CPSB, Cysteine protease, Preprocathepsin B, APP secretase, APPS
Target Sequences: NM_001908 NP_001899.1 P07858

Publications (1)

1
Autophagy in Pancreatic Acinar Cells in Caerulein-treated Mice: Immunolocalization of Related Proteins and Their Potential as Markers of Pancreatitis. Zhang L, Zhang J, Shea K, Xu L, Tobin G, Knapton A, Sharron S, Rouse R. Toxicologic pathology. 2013 42:435-57. (ICC, WB; Human, Rat) [Full Text Article] [PubMed:23640381]

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CTSB / Cathepsin B Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
CTSB / Cathepsin B Rabbit anti-Human Polyclonal (aa198-227) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$460
CTSB / Cathepsin B ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Human
250 - 16000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$534
CTSB / Cathepsin B Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
CTSB / Cathepsin B Goat anti-Human Polyclonal (Internal Region) Antibody
Human
Flo, IF, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
CTSB / Cathepsin B Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CTSB / Cathepsin B Goat anti-Human Polyclonal (Internal Region) Antibody
Human
Flo, IF, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$460
CTSB / Cathepsin B ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
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CTSB / Cathepsin B Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µg/$341
CTSB / Cathepsin B Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CTSB / Cathepsin B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
CTSB / Cathepsin B Antibody - Immunohistochemistry-Paraffin: Cathepsin B Antibody - Human brain tissue.
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CTSB / Cathepsin B Rabbit anti-Human Polyclonal (aa200-270) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
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CTSB / Cathepsin B Rabbit anti-Mouse Monoclonal (Preservative Free) (010) Antibody
Mouse
IHC-P
Unconjugated, Preservative Free
100 µl/$412
CTSB / Cathepsin B Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
CTSB / Cathepsin B Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human, Monkey
IHC-P, WB
Unconjugated
50 µl/$460
CTSB / Cathepsin B Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using CTSB Antibody at dilution of 1:100
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CTSB / Cathepsin B Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
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CTSB / Cathepsin B Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
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CTSB / Cathepsin B Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
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CTSB / Cathepsin B Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
CTSB / Cathepsin B ELISA Kit
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Sandwich
96-Well Microplate
Mouse
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$559
CTSB / Cathepsin B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
CTSB / Cathepsin B Protein - Recombinant Cathepsin B By SDS-PAGE
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E. coli
His
23.9 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
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CTSB / Cathepsin B Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$412
CTSB / Cathepsin B Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CTSB / Cathepsin B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC-P
Unconjugated
60 µl/$460
CTSB / Cathepsin B Antibody - Immunohistochemistry analysis of Cathepsin B antibody in paraffin-embedded human brain tissue.
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CTSB / Cathepsin B Rabbit anti-Human Polyclonal (aa168-217) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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CTSB / Cathepsin B Rabbit anti-Human Polyclonal (aa198-227) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
CTSB / Cathepsin B Antibody - Western blot of Cathepsin B antibody
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CTSB / Cathepsin B Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Select
CTSB / Cathepsin B Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
100 µl/$412
CTSB / Cathepsin B Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
CTSB / Cathepsin B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC-P
Unconjugated
60 µl/$460
CTSB / Cathepsin B Antibody - IHC of Cathepsin B (N217) pAb in paraffin-embedded human brain tissue.
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CTSB / Cathepsin B Rabbit anti-Human Polyclonal (Asn217) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
Viewing 1-25 of 130 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).