Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count.
Gene Name: | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 |
Family/Subfamily: | Protease Regulatory , not assigned-Protease Regulatory |
Synonyms: | PSMD3, p58, TSTA2, Proteasome subunit p58, RPN3, S3 |
Target Sequences: | NM_002809 NP_002800.2 O43242 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.