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PDE1B belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene Name: | phosphodiesterase 1B, calmodulin-dependent |
Family/Subfamily: | Phosphodiesterase , PDE - cAMP/cGMP dual-specific, Ca/Calmodulin-dependent |
Synonyms: | PDE1B, 63 kDa Cam-PDE, Cam-PDE 1B, PDES1B, PDE1B1, PDE1B2 |
Target Sequences: | NM_000924 NP_000915.1 Q01064 |
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