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E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.
Gene Name: | ring finger protein 185 |
Synonyms: | RNF185, BSK65-MONO1, BSK65-PANC1, BSK65-PANC2, BSK65-TEST1, BSK65-TEST2, BSK65-TEST3, Ring finger protein 185, BSK65-MONO2 |
Target Sequences: | NM_152267 NP_689480.2 Q96GF1 |
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