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Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.
Gene Name: | endothelial differentiation-related factor 1 |
Synonyms: | EDF1, EDF-1, Multiprotein bridging factor 1, Multiprotein-bridging factor 1, MBF1 |
Target Sequences: | AJ005259 NP_003783.1 O60869 |
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