LSBio logo with text
Products
Research Areas
COVID-19
Resources
Contact Us
Login
Quick Order
Cart Cart lightblue
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Cart
How To Buy
Contact Us

Location

Corporate Headquarters

Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States

Telephone Numbers


Customer Service: (800) 227-6666 / (650) 697-3600


Contact Us


Additional Contact Details

Distributors
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

XRCC3

X-ray repair complementing defective repair in Chinese hamster cells 3

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.

Gene Name: X-ray repair complementing defective repair in Chinese hamster cells 3
Synonyms: XRCC3, DNA repair protein XRCC3, CMM6
Target Sequences: NM_005432 NP_005423.1 O43542

Publications (15)

1
XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells. Yoshihara T, Ishida M, Kinomura A, Katsura M, Tsuruga T, Tashiro S, Asahara T, Miyagawa K. The EMBO journal. 2004 23:670-80. (IP; Human) [PubMed:14749735] [PMC:PMC1271813]
2
Xrcc3 is recruited to DNA double strand breaks early and independent of Rad51. Forget AL, Bennett BT, Knight KL. Journal of cellular biochemistry. 2004 93:429-36. (ICC) [PubMed:15372620]
3
Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression. Fan R, Kumaravel TS, Jalali F, Marrano P, Squire JA, Bristow RG. Cancer research. 2004 64:8526-33. [PubMed:15574758]
4
Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51. Bennett BT, Knight KL. Journal of cellular biochemistry. 2005 96:1095-109. [PubMed:16215984]
5
Role for RAD18 in homologous recombination in DT40 cells. Szts D, Simpson LJ, Kabani S, Yamazoe M, Sale JE. Molecular and cellular biology. 2006 26:8032-41. [PubMed:16923963] [PMC:PMC1636725]
6
Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C. Nagaraju G, Odate S, Xie A, Scully R. Molecular and cellular biology. 2006 26:8075-86. [PubMed:16954385] [PMC:PMC1636746]
7
Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells. Compton SA, Choi JH, Cesare AJ, Ozgr S, Griffith JD. Cancer research. 2007 67:1513-9. [PubMed:17308089]
8
Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance. Chan N, Koritzinsky M, Zhao H, Bindra R, Glazer PM, Powell S, Belmaaza A, Wouters B, Bristow RG. Cancer research. 2008 68:605-14. [PubMed:18199558]
9
WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening. Li B, Jog SP, Reddy S, Comai L. Molecular and cellular biology. 2008 28:1892-904. [PubMed:18212065] [PMC:PMC2268394]
10
Dysfunctional homologous recombination mediates genomic instability and progression in myeloma. Shammas MA, Shmookler Reis RJ, Koley H, Batchu RB, Li C, Munshi NC. Blood. 2009 113:2290-7. [PubMed:19050310] [PMC:PMC2652372]
11
The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction. Katsura M, Tsuruga T, Date O, Yoshihara T, Ishida M, Tomoda Y, Okajima M, Takaku M, Kurumizaka H, Kinomura A, Mishima HK, Miyagawa K. Nucleic acids research. 2009 37:3959-68. [PubMed:19403737] [PMC:PMC2709562]
12
The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links. Al-Minawi AZ, Lee YF, Hkansson D, Johansson F, Lundin C, Saleh-Gohari N, Schultz N, Jenssen D, Bryant HE, Meuth M, Hinz JM, Helleday T. Nucleic acids research. 2009 37:6400-13. [PubMed:19713438] [PMC:PMC2770670]
13
Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C. Gildemeister OS, Sage JM, Knight KL. The Journal of biological chemistry. 2009 284:31945-52. [PubMed:19783859] [PMC:PMC2797266]
14
Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome. Sage JM, Gildemeister OS, Knight KL. The Journal of biological chemistry. 2010 285:18984-90. [PubMed:20413593] [PMC:PMC2885175]
15
Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta. Nicolay NH, Carter R, Hatch SB, Schultz N, Prevo R, McKenna WG, Helleday T, Sharma RA. Carcinogenesis. 2012 33:2026-34. (WB; Human) [PubMed:22822095] [PMC:PMC3584963]
more

☰ Filters
Antibodies (44)
Proteins (13)
Over-Expression Lysate (9)
Primary (44)
Recombinant (4)
XRCC3 (57)
Human (43)
Mouse (8)
Rat (6)
Bovine (3)
Chimpanzee (6)
Gibbon (6)
Monkey (3)
Rabbit (3)
Rodent (1)
IHC (18)
IHC-Fr (1)
IHC-P (9)
WB (36)
ELISA (9)
ICC (2)
IF (5)
Peptide-ELISA (3)
rabbit (34)
mouse (10)
Product Group
IHCPlus (1)
IgG (15)
IgG1 (8)
IgG2a,k (1)
monoclonal mc (9)
polyclonal pc (35)
1H7 (1)
OTI1C1 (2)
OTI4C8 (2)
OTI4F3 (2)
OTI5B11 (2)
Biotin Conjugated (4)
Carrier-free (4)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (3)
HRP Conjugated (3)
Preservative Free (1)
Unconjugated (31)
aa1-235 (8)
C-Terminus (4)
aa1-316 (4)
aa122-171 (4)
aa41-90 (2)
10-90 aa, Internal (1)
Internal (1)
aa202-346 (1)
aa290-305 (1)
No (57)
GST (1)
His (1)
His, N-Terminal (1)
His-SUMO (1)
Myc-DDK (Flag) (9)
Human (9)
293T Cells (5)
E. coli (3)
HEK 293 Cells (4)
Wheat Germ Extract (1)
Purified (3)
XRCC3 Antibody - Anti-XRCC3 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
IHC-plus™ XRCC3 Antibody LS-B319
(4.0) Rating
XRCC3 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P
Unconjugated
0.1 ml/$460
XRCC3 Antibody - Anti-XRCC3 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
XRCC3 Antibody (Biotin) LS-C140841
XRCC3 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
XRCC3 Antibody - Anti-XRCC3 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
XRCC3 Antibody (DY488) LS-C140843
XRCC3 Rabbit anti-Human Polyclonal (DY488) Antibody
Human
IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
XRCC3 Antibody - Anti-XRCC3 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
XRCC3 Antibody (DY650) LS-C140842
XRCC3 Rabbit anti-Human Polyclonal (DY650) Antibody
Human
IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
XRCC3 Antibody - Anti-XRCC3 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
XRCC3 Antibody (DY550) LS-C140845
XRCC3 Rabbit anti-Human Polyclonal (DY550) Antibody
Human
IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
XRCC3 Antibody - 1:100 staining human lung carcinoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
XRCC3 Antibody LS-C800416
XRCC3 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
XRCC3 Antibody LS-C11109
XRCC3 Rabbit anti-Human Polyclonal Antibody
Rodent, Human
ELISA, ICC, IHC, IHC-Fr, WB
Unconjugated
50 µg/$720
XRCC3 Antibody - Immunohistochemistry of paraffin-embedded rat testis.
Select
XRCC3 Antibody LS-C331928
XRCC3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
XRCC3 Antibody - Immunohistochemistry analysis of paraffin-embedded human tonsil tissue, using XRCC3 Antibody. The picture on the right is blocked with the synthesized peptide.
Select
XRCC3 Antibody (aa41-90) LS-C119599
XRCC3 Rabbit anti-Human Polyclonal (aa41-90) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
XRCC3 Protein - 12.5% SDS-PAGE of human XRCC3 stained with Coomassie Blue
Select
Human XRCC3 Protein (Recombinant GST) (Full Length) - LS-G30919
Wheat Germ Extract
GST
63.69 kDa
10 µg/$479; 25 µg/$670
Select
XRCC3 Antibody LS-C771869
XRCC3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
XRCC3 Antibody - IHC analysis of XRCC3 using anti-XRCC3 antibody. XRCC3 was detected in paraffin-embedded section of rat brain tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-XRCC3 Antibody overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
Select
XRCC3 Antibody (aa290-305) LS-C312851
XRCC3 Rabbit anti-Mouse Polyclonal (aa290-305) Antibody
Mouse, Rat
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
XRCC3 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human tonsil tissue using XRCC3 antibody.
Select
XRCC3 Antibody LS-C823641
XRCC3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
100 µg/$357
XRCC3 Antibody - Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using XRCC3 Antibody. The picture on the right is blocked with the synthesized peptide.
Select
XRCC3 Antibody (aa41-90) LS-C118641
XRCC3 Rabbit anti-Human Polyclonal (aa41-90) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
XRCC3 Antibody - Western blot of XRCC3 antibody
Select
XRCC3 Antibody (10-90 aa, Internal) LS-C386688
XRCC3 Rabbit anti-Human Polyclonal (10-90 aa, Internal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
XRCC3 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using XRCC3 antibody.
Select
XRCC3 Antibody LS-C821762
XRCC3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
XRCC3 Antibody - Immunohistochemical analysis of XRCC3 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
XRCC3 Antibody (Internal) LS-C353014
XRCC3 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P, WB
Unconjugated
30 µl/$255; 50 µl/$271; 100 µl/$299; 200 µl/$351
XRCC3 Antibody - Western blot of extracts of various cell lines, using XRCC3 antibody.
Select
XRCC3 Antibody LS-C192513
XRCC3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
XRCC3 Antibody - Western blot of HepG2 cell lysate using XRCC3 Antibody
Select
XRCC3 Antibody LS-C415992
XRCC3 Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
50 µl/$305; 100 µl/$357
XRCC3 Antibody - Immunofluorescence of paraformaldehyde-fixed HeLa using XRCC3 antibody at 1:200 dilution.
Select
XRCC3 Antibody (aa202-346) LS-C185340
XRCC3 Rabbit anti-Human Polyclonal (aa202-346) Antibody
Human
ICC, WB
Unconjugated
100 µl/$450
XRCC3 Antibody - Detection limit for recombinant GST tagged XRCC3 is 3 ng/ml as a capture antibody.
Select
XRCC3 Antibody (clone 1H7) LS-C198446
XRCC3 Mouse anti-Human Monoclonal (1H7) Antibody
Human
ELISA
Unconjugated
100 µg/$423
XRCC3 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY XRCC3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-XRCC3.
Select
XRCC3 Antibody (aa1-235, clone OTI4F3) LS-C339310
XRCC3 Mouse anti-Human Monoclonal (aa1-235) (OTI4F3) Antibody
Human
WB
Unconjugated
100 µl/$434
XRCC3 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY XRCC3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-XRCC3.
Select
XRCC3 Antibody (aa1-235, clone OTI4C8) LS-C339311
XRCC3 Mouse anti-Human Monoclonal (aa1-235) (OTI4C8) Antibody
Human
WB
Unconjugated
100 µl/$434
XRCC3 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY XRCC3. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-XRCC3.
Select
XRCC3 Antibody (aa1-235, clone OTI4C8, Carrier-free) LS-C790361
XRCC3 Mouse anti-Human Monoclonal (aa1-235) (Carrier-free) (OTI4C8) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
XRCC3 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY XRCC3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-XRCC3.
Select
XRCC3 Antibody (aa1-235, clone OTI5B11) LS-C339314
XRCC3 Mouse anti-Human Monoclonal (aa1-235) (OTI5B11) Antibody
Human
WB
Unconjugated
100 µl/$434
Viewing 1-25 of 57 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

Family of Companies
Site Links Home All Antibodies How To Buy All Proteins Distributors All ELISA & Assay Kits Reviews PathPlus™ Antibodies
Follow LSBio View Cart Register or Login
Copyright © 2024 LifeSpan BioSciences, Inc - Privacy Policy
Contact Us

Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States

Tel: (800) 227-6666 / (650) 697-3600

Orders:
customerservice@vectorlabs.com

For technical assistance:
Technical.Support@LSBio.com